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time-resolved distorsion-product otoacoustic emissions

时间分辨畸变产物耳声发射

基本信息

批准号：
209020563
负责人：
Dr.-Ing. Ernst Dalhoff
金额：
--
依托单位：
Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/209020563?language=en
关键词：
time resolved distorsion product otoacoustic

项目摘要

In audiometry, an objective, sensitive and specific method for evaluation of dysfunctions of the inner ear is required. Estimation of hearing threshold using extrapolation of I/O functions of distortion-product otoacoustic emissions (DPOAE) is one such method. Unfortunately, interaction of two source contributions from different places in the cochlea lead to a so-called fine structure which introduces errors in the threshold estimations in the manner as they are used to date. Methods to suppress DPOAE fine structure currently under investigation in hearing research are either too time consuming to become part of clinical praxis, or they are not suited for the recording of I/O functions and therefore not applicable for threshold estimation.Pulsed DPOAE offer the possibility to suppress fine structure within acceptable measuring time. Therefore, pulsed DPOAE shall be developed to clinical practicability. We expect that with this technique assessment of the state of the inner ear will be possible with considerably reduced uncertainty. This is of interest for basic research because in humans application of invasive investigations used in animal experiments can not be performed. Moreover, a clinically applicable method to reduce the uncertainty of estimations of the state of the cochlea offers new perspectives for diagnostic and therapy of adult patients, but especially childs and newborns.

在听力学中，需要一种客观、灵敏和具体的方法来评估内耳功能障碍。利用失真积耳声发射（DPOAE）的I/O函数外推来估计听阈值就是这样一种方法。不幸的是，来自耳蜗不同位置的两个源的相互作用导致了所谓的精细结构，这在阈值估计中引入了迄今为止使用的方式的错误。听力研究中目前正在研究的抑制DPOAE精细结构的方法，要么耗时太长，无法应用于临床，要么不适合记录I/O功能，因此不适用于阈值估计。脉冲DPOAE提供了在可接受的测量时间内抑制精细结构的可能性。因此，脉冲DPOAE应向临床实用性发展。我们期望通过这种技术对内耳状态的评估可以大大减少不确定性。这是对基础研究的兴趣，因为在人类中不能进行在动物实验中使用的侵入性调查。此外，一种临床适用的方法来减少耳蜗状态估计的不确定性，为成人患者，特别是儿童和新生儿的诊断和治疗提供了新的视角。