SBIR Phase I: Engineered Sensors for the Pulmonary Forced Oscillation Technique

SBIR 第一阶段：用于肺强迫振荡技术的工程传感器

• 批准号: 1248714
• 负责人: Charles Forbes
• 金额: $ 14.98万
• 依托单位: Feather Sensors, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1248714&HistoricalAwards=false
• 关键词: SBIR; Phase; Engineered; Sensors; Pulmonary

This Small Business Innovation Research Phase I project will advance the development of a new pulmonary testing instrument. The innovative device utilizes a strain gauge to measure pulmonary airflow, an indicator critical in monitoring the health of asthma and chronic obstructive pulmonary disease (COPD) patients. The research challenge is to develop and demonstrate the feasibility of a customized strain gauge for this device. This will involve fabricating and testing thin film sensors and comparing their efficacy to the commercial sensor now used. The customized sensors will be developed in a university-based clean room and tested against the commercial sensors by comparing signal to noise measurements. Research efforts will aim at improving signal to noise and minimizing non-linear responses seen in the commercial sensor. For this proposal, the specific application of the new sensor will be in a device that will measure pulmonary airflow resistance using the Forced Oscillation Technique (FOT). The broader impact/commercial potential of this project will be to market an instrument that has significant advantages over those currently in use to measure lung airflow of pulmonary disease patients. An estimated 36.4 million Americans suffer from asthma or chronic obstructive pulmonary disease (COPD). Successful development of the proposed assistive technology will offer a low-cost, easily cleaned, readily mobile testing device that is adaptable to home use. The specific application proposed for this device, forced oscillation technique (FOT), has a significant advantage over standard spirometry, as it does not depend upon deliberate cooperation of the patient to perform required respiratory maneuvers. It is therefore useful for comatose patients, infants and children, mentally and physically impaired individuals, and even animals. FOT devices are new developments; they are being used primarily in research settings. The device proposed here will be extremely competitive in the marketplace, primarily due to its low cost, but also to its simple design and ease of use. Software developed for his device will make the wireless transfer of data from the patient?s home to the physician?s office effortless.

这个小型企业创新研究第一阶段项目将推进一种新的肺部检测仪器的开发。 该创新设备利用应变仪测量肺气流，这是监测哮喘和慢性阻塞性肺病（COPD）患者健康的关键指标。 研究的挑战是开发和证明这种设备的定制应变计的可行性。 这将涉及制造和测试薄膜传感器，并将其功效与目前使用的商业传感器进行比较。 定制的传感器将在大学的洁净室中开发，并通过比较信号与噪声测量结果来测试商业传感器。 研究工作的目标是提高信噪比，并最大限度地减少商业传感器中的非线性响应。 对于该提案，新传感器的具体应用将是使用强制振荡技术（FOT）测量肺气流阻力的设备。 该项目更广泛的影响/商业潜力将是销售一种仪器，该仪器比目前用于测量肺部疾病患者肺气流的仪器具有显著优势。 据估计，3640万美国人患有哮喘或慢性阻塞性肺病（COPD）。 所提出的辅助技术的成功开发将提供一种低成本、易于清洁、易于移动的测试设备，该设备适用于家庭使用。 针对该器械提出的特定应用，即强制振荡技术（FOT），与标准肺量计相比具有显著优势，因为它不依赖于患者的刻意配合来执行所需的呼吸操作。 因此，它可用于昏迷患者、婴儿和儿童、精神和身体受损的个体，甚至动物。 FOT设备是新的发展;它们主要用于研究环境。 这里提出的装置在市场上极具竞争力，这主要是由于其成本低，但也由于其简单的设计和易于使用。 为他的设备开发的软件将使病人的数据无线传输？医生的家在哪里？办公室轻松。