CAREER: A GENERALIZED APPROACH TO THE CHARACTERIZATION OF NATIVE RNA WITHIN THE CELLULAR MILIEU-AN INTEGRATED EDUCATION AND RESEARCH STUDY

职业生涯：细胞环境中天然 RNA 表征的通用方法 - 综合教育和研究

• 批准号: 1253691
• 负责人: Philip Santangelo
• 金额: $ 23.66万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1253691&HistoricalAwards=false
• 关键词: CAREER; GENERALIZED; APPROACH; CHARACTERIZATION; NATIVE

1253691 - SantangeloThe overall focus of the research and education components of this work is on the integration of cell biology and molecular engineering. Within the research component, integration of these disciplines will be utilized in the development of a generalized approach for the sensing and characterization of RNA molecules in the cellular milieu, based on previously published single RNA sensitive imaging probes. This approach will then be applied to the study of megakaryocytes, which recently were discovered to sort RNAs to sites of platelet formation. In the education portion of this proposal, the goal is to create education modules, utilizing active learning experiences, at both the undergraduate and secondary school level, that facilitate the ability of students to integrate engineering principles and biology, and new assessment strategies will be employed in order to gauge their utility. This proposal is targeted to have broad impact at both the scientific level and within society. From a scientific perspective, given the role of RNA in almost every biological problem, new tools that allow for its thorough characterization will impact the science of many researchers. On a societal level, by improving the ability of students to integrate engineering approaches with cellular biology, we?ll be able to improve their general ability to think critically and solve problems using all the tools they have been exposed to during their education.

1253691 - santangelo这项工作的研究和教育部分的总体重点是细胞生物学和分子工程的整合。在研究部分，这些学科的整合将被用于开发一种基于先前发表的单RNA敏感成像探针的细胞环境中RNA分子的传感和表征的通用方法。这种方法随后将被应用于巨核细胞的研究，巨核细胞最近被发现能够将rna分类到血小板形成的位点。在本提案的教育部分，目标是创建教育模块，利用积极的学习经验，在本科和中学阶段，促进学生整合工程原理和生物学的能力，并将采用新的评估策略，以衡量其效用。这一建议的目标是在科学层面和社会层面产生广泛的影响。从科学的角度来看，考虑到RNA在几乎所有生物学问题中的作用，允许其彻底表征的新工具将影响许多研究人员的科学。在社会层面上，通过提高学生将工程方法与细胞生物学相结合的能力，我们？他们将能够提高他们批判性思考和解决问题的能力，使用他们在教育中接触到的所有工具。