Cross Talk between Metabolism and the Nervous System via NMDAR Initiates Interbout Arousal In Hibernating Ground Squirrels

该项目利用冬眠的北极地松鼠的代谢静止来研究营养需求如何转化为神经信号。整个研究计划旨在破译将食物转化为细胞构建块的生化途径如何与那些导致神经信号分子合成的途径汇合，特别是神经递质谷氨酸。除了其直接目标之外，该项目的成果将与我们对气候变化和营养供应对脆弱的北极物种的影响的理解以及我们对许多生物的营养反应和代谢平衡的理解具有重要的相关性。这项研究将涉及阿拉斯加土著学生和当地社区的外展活动。同时，新的和先进的技术和仪器将被引入到EPSCOR州立大学的培训和研究项目中。该项目生成的所有数据都将在ftp://www.brains-hibernation.iab.alaska.edu的数据存储库中公开提供。

This project takes advantage of the metabolic quiescence of hibernating arctic ground squirrels to study how nutritional needs are translated into neural signals. The overall research plan is aimed at deciphering how the biochemical pathways that convert food to cellular building blocks converge with those that lead to the synthesis of neural signaling molecules, specifically, the neurotransmitter glutamate. Aside from its direct aims, the project outcomes will have significant relevance to our understanding of the impact that climate change and nutrient availability have on a vulnerable Arctic species and to our understanding of nutritional responses and metabolic balance in many organisms. The research will involve Alaska Native students and outreach activities for the local community. As well, new and advanced technologies and instrumentation will be introduced into training and research programs at this EPSCOR state University. All data generated from this project will be made publicly available in a data repository at ftp://www.brains-hibernation.iab.alaska.edu.