Cross Talk between Metabolism and the Nervous System via NMDAR Initiates Interbout Arousal In Hibernating Ground Squirrels

新陈代谢和神经系统之间通过 NMDAR 的交互作用启动冬眠地松鼠的间歇性唤醒

• 批准号: 1258179
• 负责人: Kelly Drew
• 金额: $ 96.3万
• 依托单位: University of Alaska Fairbanks Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1258179&HistoricalAwards=false
• 关键词: Cross; Talk; between; Metabolism; Nervous

This project takes advantage of the metabolic quiescence of hibernating arctic ground squirrels to study how nutritional needs are translated into neural signals. The overall research plan is aimed at deciphering how the biochemical pathways that convert food to cellular building blocks converge with those that lead to the synthesis of neural signaling molecules, specifically, the neurotransmitter glutamate. Aside from its direct aims, the project outcomes will have significant relevance to our understanding of the impact that climate change and nutrient availability have on a vulnerable Arctic species and to our understanding of nutritional responses and metabolic balance in many organisms. The research will involve Alaska Native students and outreach activities for the local community. As well, new and advanced technologies and instrumentation will be introduced into training and research programs at this EPSCOR state University. All data generated from this project will be made publicly available in a data repository at ftp://www.brains-hibernation.iab.alaska.edu.

该项目利用冬眠的北极地松鼠的代谢静止来研究营养需求如何转化为神经信号。 总体研究计划旨在破译将食物转化为细胞构建块的生化途径如何与导致神经信号分子合成的生化途径汇合，特别是神经递质谷氨酸。 除了其直接目标外，该项目的成果将对我们理解气候变化和营养物质供应对北极脆弱物种的影响以及我们对许多生物体的营养反应和代谢平衡的理解具有重要意义。这项研究将涉及阿拉斯加土著学生和当地社区的外联活动。 此外，新的和先进的技术和仪器将被引入到这个EPSCOR州立大学的培训和研究计划。 该项目产生的所有数据将在ftp://www.brains-hibernation.iab.alaska.edu的数据库中公开提供。