2013 Cardiac Arrhythmia Mechanisms GRC, February 17-22, 2013, Ventura, CA

2013 心律失常机制 GRC，2013 年 2 月 17-22 日，加利福尼亚州文图拉

• 批准号: 1260205
• 负责人: Mario Delmar
• 金额: $ 0.5万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1260205&HistoricalAwards=false
• 关键词: 2013; Cardiac; Arrhythmia; Mechanisms; GRC

1260205DelmarIntellectual Merit. The main objective of this Gordon Research Conference (GRC) is to serve as a vehicle for scientific dialogue between and among experts and trainees interested in the fundamental mechanisms of cardiac arrhythmias, which are a leading cause of morbidity and mortality in the industrialized world. The conference has taken place every two years since 2003. Thanks in part to support from the NSF, this conference has become the premier forum for free and informal exchange of novel, unpublished and high impact information in this field. This GRC is a unique stage for interdisciplinary discourse, networking, and creative design of new research. Great strides in the understanding of cardiac arrhythmias have resulted from the marriage of cardiac electrophysiology with biomedical engineering. Novel approaches to study cell/tissue/organ electrical behavior will be discussed in the conference, including new imaging modalities, tissue engineering, single-molecule fluorescence microscopy, scanning ion conductance microscopy, optogenetics, intracardiac and epicardial electrode mapping, MRI and computer modeling, among others. Other presentations will discuss novel experimental biological models (zebrafish, stem cells, and novel transgenic animals) that provide exciting platforms for implementation of advances in engineering. Additional talks will focus on the mechanisms of arrhythmias at the systems level, an area where MRI and computer modeling have merged with clinical cardiology to gain insight into the origin of arrhythmias in humans. The meeting brings together outstanding senior investigators and promising young scientists at the forefront of research, with expertise in cell/molecular biology, electrophysiology, biophysics, biomedical engineering, instrument design, mathematical biology, systems biology and clinical cardiology. No other existing conference provides a comparable forum where experts and trainees in biomedical engineering share the floor with those interested in the biology of the cardiac rhythm for informal and in-depth discussion. The educational value of this framework is extremely high, well recognized and as such, well sought-after by trainees and mentors alike.Broader Impacts. This conference has broad and substantial impact. Cardiac arrhythmias are a major cause of mortality and morbidity in the developed world. Yet, the mechanisms of deadly arrhythmias remain to be elucidated. Basic research is desperately needed, so that new avenues of understanding can be opened, for future benefit of the population at risk. One of the keys to success for this GRC is the fostering of an informal, friendly environment that facilitates open discussion. The conference is, from beginning to end, an exercise in dissemination of high impact science, and in training of new investigators. Trainees find this an ideal environment to network with peers and faculty. Seniority barriers are easier to tear down, providing the perfect environment for bi-directional teaching and learning. The interdisciplinary nature of the conference allows a student of one discipline to interact closely with an expert in a parallel field, facilitating discovery of common interests and hopefully, the joining of ventures. The organizers have consistently placed great effort to increase the participation of minorities (in fact, the present Chair is Mexican-American). Participation of women has increased progressively as well. In case the meeting becomes oversubscribed, the priority is given to women and minorities. Several approaches have been implemented to foster scientific exchange between trainees and faculty. The requested financial assistance will help increase the number of women and minority participants, particularly at the junior level.In summary, this Gordon Research Conference is the only one of its kind that brings together experts and trainees in engineering and biomedicine for a dynamic educational experience based on the free exchange of novel data, and the development of new ideas, with one common goal: to increase our understanding of the mechanisms that regulate the heart beat.

1260205德尔玛智力功绩。本次戈登研究会议（GRC）的主要目标是作为一个工具，为专家和学员之间的科学对话感兴趣的心律失常的基本机制，这是在工业化世界的发病率和死亡率的主要原因。自2003年以来，该会议每两年举行一次。部分由于NSF的支持，本次会议已成为该领域新颖，未发表和高影响力信息的自由和非正式交流的首要论坛。这个GRC是跨学科话语，网络和新研究的创造性设计的独特舞台。心脏电生理学与生物医学工程学的结合，使心律失常的认识有了长足的进步。会议将讨论研究细胞/组织/器官电行为的新方法，包括新的成像方式，组织工程，单分子荧光显微镜，扫描离子电导显微镜，光遗传学，心内和心外膜电极映射，MRI和计算机建模等。其他演讲将讨论新的实验生物模型（斑马鱼，干细胞和新的转基因动物），为工程进展的实施提供令人兴奋的平台。额外的会谈将集中在系统层面的心律失常机制，MRI和计算机建模与临床心脏病学相结合的领域，以深入了解人类心律失常的起源。会议汇集了优秀的高级研究人员和有前途的年轻科学家在研究的前沿，在细胞/分子生物学，电生理学，生物物理学，生物医学工程，仪器设计，数学生物学，系统生物学和临床心脏病学的专业知识。没有其他现有的会议提供了一个类似的论坛，生物医学工程的专家和学员与那些对心律生物学感兴趣的人进行非正式和深入的讨论。这一框架的教育价值极高，得到了学员和导师的广泛认可，并因此受到追捧。更广泛的影响。这次会议具有广泛而实质性的影响。心律失常是发达国家死亡率和发病率的主要原因。然而，致命性心律失常的机制仍有待阐明。迫切需要基础研究，以便开辟新的理解途径，为未来处于危险中的人口造福。本区域协商会议成功的关键之一是营造一种非正式、友好的环境，促进公开讨论。会议自始至终都是传播高影响力科学和培训新研究人员的一次演习。学员发现这是一个理想的环境，与同行和教师网络。资历障碍更容易拆除，为双向教学提供了完美的环境。会议的跨学科性质允许一个学科的学生与平行领域的专家密切互动，促进共同利益的发现，并希望加入企业。组织者一直在努力增加少数群体的参与（事实上，现任主席是墨西哥裔美国人）。妇女的参与也在逐步增加。如果会议报名过多，则优先考虑妇女和少数民族。已采取若干办法促进受训人员和教员之间的科学交流。所要求的财政援助将有助于增加妇女和少数民族参与者的人数，特别是在初级一级。总而言之，这次戈登研究会议是唯一一次将工程和生物医学领域的专家和学员聚集在一起，在自由交流新数据的基础上进行动态教育体验，并发展新的想法，有一个共同的目标：来增加我们对调节心跳的机制的理解。