Computational Studies of Protein Powder Hydration Phenomena

摘要本项目将使用先进的分子模拟工具来研究和量化水合水平、碳水化合物辅料和温度等关键变量对蛋白质脱水和再水合过程中结构、稳定性和动力学的影响。该项目的成功成果将有助于开发高质量的治疗性蛋白质，并推动制药行业治疗方法的发展。

AbstractThis PI will use advanced molecular simulation tools to investigate and quantify the effects of key variables such as hydration level, carbohydrate excipients, and temperature on the structure, stability and dynamics of proteins undergoing dehydration and rehydration. The impact from the successful outcome of this project will help develop quality therapeutic proteins and advance the development such therapeutics for the pharmaceutical industry.