Low-cost silicon photonic biosensors for enhanced label-free detection in complex media

摘要CBET - 1264174 Ratner，丹尼尔该提案的目的是通过显著降低光源的尺寸和成本，同时通过（1）设计用于低成本激光器的新型集成硅纳米光子器件的组合和（2）针对标记优化的界面化学来增强性能，从而将硅光子生物传感器技术推向临床应用。在复杂的生物介质中进行自由检测？包括血液、血浆和血清。具体来说，他们将开发与低成本激光源兼容的高灵敏度狭缝波导布拉格光栅和干涉仪波导传感器。这些设备将被设计用于检测小的分析物（例如蛋白质和小分子）和较大的颗粒（例如细胞，细胞碎片，病毒），提供灵活性，以支持生物医学研究人员和临床医生的不同需求。

ABSTRACT CBET - 1264174 Ratner, Daniel The objective of this proposal is to advance silicon photonic biosensor technology towards clinical use by dramatically reducing the size and cost of the optical source while enhancing performance through (1) the combination of novel integrated silicon nanophotonic devices designed for use with low-cost lasers and (2) interfacial chemistries optimized for label-free detection in complex biological media?including blood, plasma, and serum. Specifically, they will develop highly sensitive slot-waveguide Bragg grating and ultrathin interferometer waveguide sensors that are compatible with low-cost laser sources. These devices will be designed to detect small analytes (e.g. proteins and small molecules) and larger particles (e.g. cells, cell fragments, viruses), providing the flexibility to support the diverse needs of biomedical researchers and clinicians.