Collaborative Research: Stepwise Functionalization and Surface Modification for ZnO Nanostructure-based Biosensors

1264508(Lu)拟议研究的目标是对纳米氧化锌和氧化镁以及生物分子的表面和界面化学进行深入的科学了解，以便在分子水平上设计和开发创新的表面功能化，以使新一代生物传感器具有超高的灵敏度和选择性，并实现多模式操作。这一多学科的研究将包括MOCVD生长尺寸和形貌可控的氧化锌和氧化镁纳米结构、分子连接层的化学结合的设计和实验、氧化锌/有机分子界面的综合表征以及用于传感应用的功能化技术的实现。主要方法包括(I)合成尺寸、形貌和表面润湿性可控的高度有序的氧化锌和氧化镁纳米结构；(Ii)研究这些纳米结构和分子连接层之间的光物理和化学性质，通过使用探针生色团来实现对界面化学的前所未有的了解；以及(Iii)实施界面化学来设计和开发应用于基于氧化锌纳米结构的生物传感器的表面功能化技术。公开声明：该项目将研究如何将对传感器开发至关重要的分子，如抗体或酶，固定在纳米材料上。确保生物分子在固定化后的良好功能是成功开发生物传感器的关键，这一提议将开发新的固定化策略。

1264508(Lu) The goal of the proposed research is to perform in-depth scientific understanding of surface and interface chemistry of nanostructured ZnO and MgZnO and biomolecules in order to design and develop the innovative surface functionalization at the molecular level to enable a new generation of biosensors with ultra-high sensitivity and selectivity, and multi-modal operation. This multidisciplinary research will include MOCVD growth of ZnO and MgZnO nanostructures with controlled dimension and morphology, design and experiments of chemical binding of molecular linker layers, comprehensive characterization of the ZnO/organic molecule interfaces, and implementation of the functionalization technology for sensing applications. The main approach includes (i) synthesis of highly ordered ZnO and MgZnO nanostructures with controlled dimension, morphologies, and surface wettability; (ii) Study of the photophysical and chemical properties between these nanostructures and the molecular linker layers designed by using the probe chromophores to achieve unprecedented understanding of the interfacial chemistry, and (iii) Implementation of the interfacial chemistry to design and develop the surface functionalization technology for application in the ZnO nanostructure-based biosensors.General public statement:This project will study how molecules important in sensor development, for example antibodies or enzymes, may be immobilized on nanomaterials. Ensuring that biomolecules function well after immobilization is critical to the successful development of biosensors and this proposal will develop new immobilization strategies.