Novel Organic Cages as Moduli for Extended Three-dimensional Networks

罗格斯大学纽瓦克分校化学系Elena Galoppini教授得到化学学部有机和大分子项目的研究计划资助，建立了一种合成方法，可以产生新型有机笼状分子。由商业上可用的金刚烷和四苯基甲烷制备的衍生物偶联得到坚固、坚硬的笼，其内部腔直径从18到28埃不等。Galoppini教授提出了一种巧妙的方法来合成有机笼结构，这种结构具有作为合成扩展的、多孔的、超分子的有机网络的模量所需的刚度。在Galoppini教授职业生涯的这个阶段，研究计划资助提供了一种利用化学的手段，并在一个竞争非常激烈的领域为NSF的研究提案开发所需的方法。可定制结构的多孔有机材料是对目前可用的多孔无机材料的有吸引力的补充。然而，这种材料的合成依赖于足够刚性的构建块，以支持单个单元的扩展三维阵列。将开发一种使用市售试剂的合成方法，以提供一系列刚性有机笼，作为构建模块。三维材料将被组装成可定制的孔隙率，以允许不同试剂的扩散和封装。

Professor Elena Galoppini, Department of Chemistry, Rutgers University at Newark is supported by the Organic and Macromolecular Program of the Chemistry Division under a Research Planning Grant to establish a synthetic methodology leading to novel organic cage molecules. Derivatives prepared from commercially available adamantanes and tetraphenylmethanes are coupled to achieve robust, rigid cages with internal cavities ranging from 18 to 28 angstroms in diameter. Professor Galoppini presents a clever approach to the synthesis of organic cage structures that possess the rigidity needed to serve as moduli for the synthesis of extended, porous, supramolecular organic networks. A Research Planning Grant at this stage in Professor Galoppini's career offers a means to exploit the chemistry, and develop the methodology needed for an NSF research proposal in a very competitive area. Porous organic materials of tailorable architecture are an attractive complement to currently available porous, inorganic materials. The synthesis of such materials, however, rests on building blocks of sufficient rigidity to support an extended three dimensional array of the individual units. A synthetic methodology using commercially available reagents will be developed to afford a series of rigid organic cages that will serve as building blocks. Three dimensional materials will be assembled with tailorable porosities to allow the diffusion and encapsulation of different reagents.