Novel Organic Cages as Moduli for Extended Three-dimensional Networks

纽瓦克罗格斯大学化学系的Elena Galoppini教授得到了化学系有机和高分子计划的支持，该计划的目的是建立一种导致新型有机笼形分子的合成方法。由市售金刚烷和四苯甲烷制备的衍生物偶联，以获得坚固、坚固的保持架，其内腔直径从18到28埃不等。Galoppini教授提出了一种巧妙的方法来合成有机笼形结构，这些笼形结构具有作为模块合成扩展的、多孔的、超分子有机网络所需的刚性。在Galoppini教授职业生涯的这个阶段，研究规划补助金提供了一种利用化学的手段，并在一个竞争非常激烈的领域开发了NSF研究提案所需的方法。可定制建筑的多孔性有机材料是目前可用的多孔性无机材料的一个有吸引力的补充。然而，这种材料的合成依赖于具有足够刚性的构建块来支撑单个单元的扩展三维阵列。将开发一种使用商业试剂的合成方法，以提供一系列用作构建块的刚性有机笼子。三维材料将用可定制的孔道组装，以允许不同试剂的扩散和封装。

Professor Elena Galoppini, Department of Chemistry, Rutgers University at Newark is supported by the Organic and Macromolecular Program of the Chemistry Division under a Research Planning Grant to establish a synthetic methodology leading to novel organic cage molecules. Derivatives prepared from commercially available adamantanes and tetraphenylmethanes are coupled to achieve robust, rigid cages with internal cavities ranging from 18 to 28 angstroms in diameter. Professor Galoppini presents a clever approach to the synthesis of organic cage structures that possess the rigidity needed to serve as moduli for the synthesis of extended, porous, supramolecular organic networks. A Research Planning Grant at this stage in Professor Galoppini's career offers a means to exploit the chemistry, and develop the methodology needed for an NSF research proposal in a very competitive area. Porous organic materials of tailorable architecture are an attractive complement to currently available porous, inorganic materials. The synthesis of such materials, however, rests on building blocks of sufficient rigidity to support an extended three dimensional array of the individual units. A synthetic methodology using commercially available reagents will be developed to afford a series of rigid organic cages that will serve as building blocks. Three dimensional materials will be assembled with tailorable porosities to allow the diffusion and encapsulation of different reagents.