Collaborative Research in Biophotonics: Implantable sensor for brain blood flow mapping

1264927/1264948 Kymissis/MaThis计划将开发一种使用薄膜有机半导体材料的生物光子学新平台，该材料能够以薄而灵活的形式产生和检测光。建议的架构既克服了以前展示的植入式系统的局限性，也克服了传统上与薄膜系统相关的挑战(环境稳定性和设备交叉耦合)。他们将使用柔性有机发光二极管(OLED)和有机光电探测器(OPD)建造一系列血流监测器，以绘制大脑中的氧合作用和总血红蛋白，并随着计划的进展在尺寸、规模和复杂性上增加。他们将使用模拟条件测试和植入设备来演示系统的功能和稳定性。该平台应用在显示领域产生重大影响的OLED技术，构建了一种用于生物研究的变革性光源，该光源能够以几乎任何配置植入，并可用于在较长时间内对大面积的反射和荧光进行成像。这个轻薄、灵活的平台可以将这一新的视角和能力带到成像、光遗传学、荧光测量和其他生物光子学应用的广泛类别中。该奖项由生物理事会的IDBR计划(用于生物研究的仪器开发)和工程局的生物光子学计划共同资助。

1264927/1264948Kymissis/MaThis program will develop a new platform for biophotonics using thin film organic semiconductor materials capable of generating and detecting light in a thin, flexible form factor. The proposed architecture overcomes both the limitations of previously demonstrated implantable systems, as well as the challenges (environmental stability and device cross-coupling) traditionally associated with thin film systems. They will build a series of blood flow monitors using flexible organic light emitting diodes (OLEDs) and organic photodetectors (OPDs) to map both oxygenation and total hemoglobin in the brain, increasing in size, scale, and complexity as the program progresses. They will demonstrate the functionality and stability of the systems using both simulated condition testing and implanted devices. This platform applies OLED technology, which has had a significant impact in displays, to build a transformative light source for biological research that is capable of implantation in nearly any configuration and can be used to image reflectance and fluorescence over large areas for extended periods of time. This thin, flexible platform can bring this new perspective and capability to a broad class of imaging, optogenetic, fluorescence measurement, and other biophotonic applications.This award is co-funded by the IDBR program (Instrument Development for Biological Research) in the BIO Directorate, and Biophotonics program in the Engineering Directorate.