Collaborative Research in Biophotonics: Implantable sensor for brain blood flow mapping

生物光子学合作研究：用于脑血流测绘的植入式传感器

• 批准号: 1264927
• 负责人: Ioannis Kymissis
• 金额: $ 30.6万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1264927&HistoricalAwards=false
• 关键词: Collaborative; Research; Biophotonics; Implantable; sensor

1264927/1264948Kymissis/MaThis program will develop a new platform for biophotonics using thin film organic semiconductor materials capable of generating and detecting light in a thin, flexible form factor. The proposed architecture overcomes both the limitations of previously demonstrated implantable systems, as well as the challenges (environmental stability and device cross-coupling) traditionally associated with thin film systems. They will build a series of blood flow monitors using flexible organic light emitting diodes (OLEDs) and organic photodetectors (OPDs) to map both oxygenation and total hemoglobin in the brain, increasing in size, scale, and complexity as the program progresses. They will demonstrate the functionality and stability of the systems using both simulated condition testing and implanted devices. This platform applies OLED technology, which has had a significant impact in displays, to build a transformative light source for biological research that is capable of implantation in nearly any configuration and can be used to image reflectance and fluorescence over large areas for extended periods of time. This thin, flexible platform can bring this new perspective and capability to a broad class of imaging, optogenetic, fluorescence measurement, and other biophotonic applications.This award is co-funded by the IDBR program (Instrument Development for Biological Research) in the BIO Directorate, and Biophotonics program in the Engineering Directorate.

1264927/1264948 Kymissis/马西斯该计划将开发一个新的生物光子学平台，使用薄膜有机半导体材料，能够以薄，灵活的形式产生和检测光。所提出的架构克服了以前证明的植入式系统的局限性，以及传统上与薄膜系统相关的挑战（环境稳定性和设备交叉耦合）。他们将使用柔性有机发光二极管（OLED）和有机光电探测器（OPD）构建一系列血流监测器，以绘制大脑中的氧合和总血红蛋白，随着计划的进展，尺寸，规模和复杂性都会增加。他们将使用模拟条件试验和植入器械证明系统的功能性和稳定性。该平台应用了OLED技术，该技术对显示器产生了重大影响，为生物研究构建了一个变革性的光源，该光源能够以几乎任何配置植入，并可用于长时间成像大面积的反射率和荧光。这款轻薄、灵活的平台可以将这种新的视角和能力带到广泛的成像、光遗传学、荧光测量和其他生物光子应用中。该奖项由BIO理事会的IDBR项目（生物研究仪器开发）和工程理事会的生物光子学项目共同资助。