I-Corps: Translation of High Frequency Irreversible Electroporation (H-FIRE) for Human Clinical Applications via the Veterinary Oncology Market

I-Corps：通过兽医肿瘤学市场将高频不可逆电穿孔 (H-FIRE) 转化为人类临床应用

• 批准号: 1265105
• 负责人: Rafael Davalos
• 金额: $ 5万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265105&HistoricalAwards=false
• 关键词: Corps; Translation; Frequency; Irreversible; Electroporation

High Frequency Irreversible Electroporation (H-FIRE) is a new, minimally invasive, non-thermal tissue ablation technique in which a tumor is exposed to bursts of very short electric fields for approximately 2 minutes. These pulses structurally rearrange the lipid bilayer of cells a target region inducing cell death. As opposed to other focal ablation techniques, H-FIRE does not affect major blood vessels, nerves or the extracellular matrix making unresectable tumors treatable. The goal of this project is to transfer fundamental technology for solid tumor treatment from the laboratory to clinical application.Development of this minimally invasive technology facilitates the treatment of tumors currently inoperable with surgical resection or other focal ablation technologies due to their proximity to critical structures such as nerves and major blood vessels. Some tumor types are known to become chemo-resistant and radiation exposure must be closely regulated, especially in younger patients. Thermal-ablation techniques suffer from heat sinking effects by local vessels and tight control of treated regions is challenging. H-FIRE has the potential to complement these other technologies as a standard of care. If successful, a direct result of this project will be the development of an instrument which will be made available for clinicians and researchers to evaluate H-FIRE based therapies.

高频不可逆电穿孔（H-FIRE）是一种新的微创非热组织消融技术，其中肿瘤暴露于非常短的电场脉冲约2分钟。这些脉冲在结构上重新排列细胞的脂质双层，靶区域诱导细胞死亡。与其他局灶性消融技术相反，H-FIRE不会影响主要血管、神经或细胞外基质，使不可切除的肿瘤成为可治疗的。该项目的目标是将实体瘤治疗的基础技术从实验室转移到临床应用中，这种微创技术的发展有助于治疗目前无法通过手术切除或其他局部消融技术进行手术的肿瘤，因为它们靠近神经和主要血管等关键结构。已知某些肿瘤类型会产生耐药性，因此必须密切控制辐射暴露，尤其是在年轻患者中。热消融技术受到局部血管的散热效应的影响，并且治疗区域的严格控制具有挑战性。H-FIRE有可能作为标准护理补充这些其他技术。如果成功，该项目的直接结果将是开发一种仪器，可供临床医生和研究人员评估基于H-FIRE的疗法。