Genetically optimized Tobacco mosaic viruses as scaffold for the in vitro generation of semiconductor bio/metal-oxide nanostructured architectures

基因优化的烟草花叶病毒作为体外生成半导体生物/金属氧化物纳米结构体系的支架

• 批准号: 210453926
• 负责人: Professor Dr. Joachim Bill
• 金额: --
• 依托单位: Abteilung Chemische Materialsynthese
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/210453926?language=en
• 关键词: Genetically; optimized; Tobacco; mosaic; viruses

The goal of this project is to establish a mild protein-based biomineralization process for the formation of defined layered semiconductors which can be employed for the production of electrical devices like field-effect transistors (FET) or sensors. To this aim, an in vitro assembly approach using different genetically modified Tobacco mosaic virus (TMV) coat proteins as protein LEGO® for the generation of surface-modified virus-like reactive rods and fibers as structure-directing 1D scaffold will be applied. Chemical bath deposition (CBD) methods for the synthesis of the semiconducting metal oxides starting with ZnO, SnO2 and CdO will be developed which are compatible with these genetically modified TMV templates at close to ambient conditions. Moreover, layer thickness, surface roughness and crystallinity of these semiconductor metal oxides are sought to be optimized and characterized. Finally, device measurements in metal oxide FET geometry (MOSFET) with TMVmutant/inorganic semiconductor hybrids will be studied. This device application needs the characterization of the new TMV/inorganic hybrid materials with respect to their electrical properties and FET characteristics. We will finally be able to tune and optimize these properties via the applied biomineralization process (surface properties of the scaffold, particle size, deposition conditions, alignment) which will finally guide the material performance of the new bio-nano FET-devices.

该项目的目标是建立一种温和的基于蛋白质的生物矿化过程，用于形成定义的分层半导体，可用于生产场效应晶体管（FET）或传感器等电气设备。为此，将应用体外组装方法，其使用不同的遗传修饰的烟草花叶病毒（TMV）外壳蛋白作为蛋白LEGO®，用于产生表面修饰的病毒样反应性杆和纤维作为结构导向的1D支架。化学浴沉积（CBD）的方法，用于合成的半导体金属氧化物开始与ZnO，SnO 2和CdO将开发这些基因修饰的TMV模板在接近环境条件下兼容。此外，寻求优化和表征这些半导体金属氧化物的层厚度、表面粗糙度和结晶度。最后，在金属氧化物场效应晶体管几何（MOSFET）与TMV突变/无机半导体混合器件的测量将进行研究。这种器件应用需要表征新的TMV/无机杂化材料的电学性能和FET特性。我们最终将能够通过应用的生物矿化过程（支架的表面特性，粒度，沉积条件，对齐）来调整和优化这些特性，这将最终指导新的生物纳米FET器件的材料性能。