Microgel catalysts mimicking glycosidases

模拟糖苷酶的微凝胶催化剂

• 批准号: 1305543
• 负责人: Susanne Striegler
• 金额: $ 36万
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1305543&HistoricalAwards=false
• 关键词: Microgel; catalysts; mimicking; glycosidases

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Susanne Striegler of the University of Arkansas at Fayetteville studies selected glyconoamidines as putative transition state analogs of glycoside hydrolysis reactions, evaluates copper(II) complexes as catalysts for glycoside hydrolysis in alkaline solution and investigates microgels catalysts derived from inverse miniemulsions. The research encompasses synthesis, spectroscopic evaluation, molecular recognition and material science and provides training opportunities for undergraduate and graduate students.The proposed catalysts are of outstanding scientific and industrial interest and are expected to provide a novel platform for a shortened synthesis of glycoconjugates and biomarkers of potential pharmacological importance as a long term goal. Further broader impacts on society include outreach efforts of the team to local high and middle schools, and the development of new classroom teaching styles to facilitate student retention, increase graduate rate, and decrease costs and preparation time until graduation.

在这个由化学部门大分子、超分子和纳米化学项目资助的项目中，费耶特维尔阿肯色大学的Susanne Striegler研究了选择的糖酰胺作为糖苷水解反应的假设过渡态类似物，评估了铜（II）配合物作为碱性溶液中糖苷水解的催化剂，并研究了由反微乳液衍生的微凝胶催化剂。研究包括合成、光谱评估、分子识别和材料科学，并为本科生和研究生提供培训机会。所提出的催化剂具有突出的科学和工业意义，并有望为糖缀合物和具有潜在药理重要性的生物标志物的缩短合成提供一个新的平台。对社会的更广泛的影响包括团队在当地高中和初中的推广工作，以及开发新的课堂教学风格，以促进学生保留，提高毕业率，减少成本和毕业前的准备时间。

项目成果

Solvent-controlled synthesis of bulky and polar-bulky galactonoamidines

• DOI: 10.1016/j.carres.2022.108520
• 发表时间: 2022-02-19
• 期刊: CARBOHYDRATE RESEARCH
• 影响因子: 3.1
• 作者: Striegler，Susanne;Orizu，Ifedi
• 通讯作者: Orizu，Ifedi