Microgel catalysts mimicking glycosidases

在这项由化学系大分子、超分子和纳米化学计划资助的项目中，阿肯色大学费耶特维尔分校的Susanne Striegler研究了糖胺类化合物作为糖苷水解反应的假定过渡态类似物，评估了铜(II)络合物作为糖苷在碱性溶液中水解的催化剂，并研究了反相微乳液衍生的微凝胶催化剂。这项研究涵盖了合成、光谱评估、分子识别和材料科学，为本科生和研究生提供了培训机会。建议的催化剂具有突出的科学和工业意义，有望为糖偶联物和具有潜在药理意义的生物标记物的短期合成提供一个新的平台作为长期目标。对社会的更广泛影响包括团队对当地高中和中学的外展努力，以及开发新的课堂教学风格，以促进学生留住，提高毕业率，并降低成本和准备毕业前的时间。

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Susanne Striegler of the University of Arkansas at Fayetteville studies selected glyconoamidines as putative transition state analogs of glycoside hydrolysis reactions, evaluates copper(II) complexes as catalysts for glycoside hydrolysis in alkaline solution and investigates microgels catalysts derived from inverse miniemulsions. The research encompasses synthesis, spectroscopic evaluation, molecular recognition and material science and provides training opportunities for undergraduate and graduate students.The proposed catalysts are of outstanding scientific and industrial interest and are expected to provide a novel platform for a shortened synthesis of glycoconjugates and biomarkers of potential pharmacological importance as a long term goal. Further broader impacts on society include outreach efforts of the team to local high and middle schools, and the development of new classroom teaching styles to facilitate student retention, increase graduate rate, and decrease costs and preparation time until graduation.