Efficient Designs for Complex Scientific Experiments

复杂科学实验的高效设计

• 批准号: 1306394
• 负责人: Sam Hedayat
• 金额: $ 13万
• 依托单位: University of Illinois at Chicago
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1306394&HistoricalAwards=false
• 关键词: Efficient; Designs; Complex; Scientific; Experiments

The investigator has two-fold purpose in this project both relate to cost-effective methods of collecting high-efficiency data in Phase I, Phase II and Phase III pharmaceutical trials involving drug discovery/drug abuse, heart-related QT/QTc studies, evaluation of new drugs for unwanted effects and also in experiments dealing with processing of minerals involving chemical reactions. Akin to PK/PD models, one requires complex non-linear models in dealing with medical/chemical/environmental studies. In this context, dwelling on Klimpels floatation recovery model, chemical kinetic model and compartment model, the investigator develops analytically sound and innovative techniques for optimal/nearly optimal estimation of the underlying model parameters with constrained experimental conditions.The aim of this proposal is to provide research practitioners in fMRI studies, medicine, and pharmacy with ready-to-use statistical/computational software for carrying out cost-effective experiments. Research outcomes on compartment models will allow formal rigorous inference and analysis based on clinical or experimental data for complicated HIV dynamic models. Research practitioners in fMRI studies, medicine, and pharmacy can save time and money by using the new to-be-developed software-based crossover designs.

研究者在该项目中有双重目的，涉及在I期、II期和III期药物试验中收集高效数据的成本效益方法，包括药物发现/药物滥用、心脏相关QT/QTc研究、评估新药的不良反应以及涉及化学反应的矿物质处理实验。类似于PK/PD模型，在处理医学/化学/环境研究时需要复杂的非线性模型。在这种情况下，居住在Klimpels浮选恢复模型，化学动力学模型和房室模型，研究者开发分析合理和创新的技术，用于最佳/接近最佳的估计基础模型参数与约束的实验条件。和药学与随时可用的统计/计算软件进行成本效益的实验。房室模型的研究成果将允许正式严格的推理和分析的基础上，复杂的艾滋病病毒的动态模型的临床或实验数据。功能磁共振成像研究、医学和药学的研究人员可以通过使用新的基于软件的交叉设计来节省时间和金钱。