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Molecular determinants of host specificity of maize-, rice- and mango-pathogenic species of the genus Fusarium

镰刀菌属玉米、水稻和芒果致病菌宿主特异性的分子决定因素

基本信息

批准号：
210882736
负责人：
Dr. Ulrich Güldener
金额：
--
依托单位：
Deutsches Herzzentrum München (DHM)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2011
资助国家：
德国
起止时间：
2010-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/210882736?language=en
关键词：
Molecular determinants host specificity maize

项目摘要

Fusarium species of the Gibberella fujikuroi species complex cause serious diseases on different crops such as rice, wheat and maize. An important group of plant pathogens is the Gibberella fujikuroi species complex (GFC) of closely related Fusarium species which are associated with specific hosts; F. verticillioides and F. proliferatum are particularly associated with maize where they can cause serious ear-, root-, and stalk rot diseases. Two other closely related species of the GFC, F. mangiferae and F. fujikuroi, which share about 90% sequence identity with F. verticillioides, are pathogens on mango and rice, respectively. All of these species produce a broad spectrum of secondary metabolites such as phytohormones (gibberellins, auxins, and cytokinins), and harmful mycotoxins, such as fumonisin, fusarin C, or fusaric acid in large quantities. However, the spectrum of those mycotoxins might differ between closely related species suggesting that secondary metabolites might be determinants for host specificity. In this project, we will study the potential impact of secondary metabolites (i.e. phytohormones and certain mycotoxins) and some other species-specific factors (e.g. species-specific transcription factors) on host specificity. The recently sequenced genomes of F. mangiferae and F. fujikuroi by our groups and the planned sequencing of F. proliferatum will help to identify such determinants by genetic manipulation of the appropriate metabolic pathway(s).

藤仓赤霉菌种复合体的镰刀菌种在不同的作物如水稻、小麦和玉米上引起严重的疾病。一组重要的植物病原体是与特定宿主密切相关的镰刀菌属物种的藤仓赤霉菌种复合体（GFC）; verticillioides和F. proliferatum尤其与玉米相关，在玉米中它们可引起严重的穗、根和茎腐烂病。GFC的另外两个密切相关的物种，F。mangiferae和F. fujikuroi，与F.轮枝菌属（verticillioides）分别是芒果和水稻上的病原菌。所有这些物种都产生广泛的次级代谢产物，如植物激素（赤霉素，生长素和细胞分裂素），以及有害的真菌毒素，如伏马菌素，镰刀菌素C或镰刀菌酸。然而，这些真菌毒素的谱可能在密切相关的物种之间存在差异，这表明次级代谢产物可能是宿主特异性的决定因素。在这个项目中，我们将研究次级代谢产物（即植物激素和某些真菌毒素）和其他一些物种特异性因子（例如物种特异性转录因子）对宿主特异性的潜在影响。对F. mangiferae和F. fujikuroi和F. Proliferatum将有助于通过适当代谢途径的遗传操作来识别这些决定因素。