Design of Stimuli-Sensitive Organic Nanoparticles through Self-Assembly

通过自组装设计刺激敏感的有机纳米粒子

• 批准号: 1307118
• 负责人: Sankaran Thayumanavan
• 金额: $ 42万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307118&HistoricalAwards=false
• 关键词: Design; Stimuli; Sensitive; Organic; Nanoparticles

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, Sankaran Thayumanavan of the University of Massachusetts at Amherst will develop methods for assembling organic nanoparticles through polymer self-assembly. The research will involve three components. In the first part, the project will focus on the development of organic nanoparticles with well-defined surface characteristics. In the second part, polymer-nanoparticle complexes will be generated using the well-defined surface functional groups of the nanoparticle and the complementary functional groups present in the polymer. The final part will involve development of strategies for eliciting fluorescence changes in the polymer-nanoparticle complexes due to the presence of large analyte molecules. The broader impacts of this project will involve interdisciplinary training of undergraduate and graduate students by cross-training the students not only across the sub-disciplines of chemistry, but also across other scientific disciplines that will see the impacts of this project. The project will also assist in broadening the participation of underrepresented groups in STEM research via participation in the Northeast Alliance for Graduate Education and Professoriate program. Nanotechnology's impact in diverse areas of present day technology starts with the ability to synthesize well-defined nanometer-sized objects (nanoparticles) with well-defined surfaces. This research project seeks to develop fundamentally new ways of synthesizing functional nanoparticles that can bind with proteins to form complex materials or to generate observable signals. Such nanoparticles could lead to versatile sensing technologies that could impact biotechnology.

在这个由化学部高分子、超分子和纳米化学项目资助的项目中，马萨诸塞大学阿默斯特分校的 Sankaran Thayumanavan 将开发通过聚合物自组装来组装有机纳米颗粒的方法。 该研究将涉及三个部分。 在第一部分中，该项目将重点开发具有明确表面特征的有机纳米颗粒。 在第二部分中，将使用纳米颗粒明确的表面官能团和聚合物中存在的互补官能团生成聚合物-纳米颗粒复合物。 最后一部分将涉及开发由于大分析物分子的存在而引发聚合物-纳米粒子复合物中的荧光变化的策略。 该项目更广泛的影响将涉及本科生和研究生的跨学科培训，不仅对化学子学科的学生进行交叉培训，而且还对其他将看到该项目影响的科学学科进行交叉培训。 该项目还将通过参与东北研究生教育和教授计划联盟，帮助扩大代表性不足的群体参与 STEM 研究。 纳米技术对当今技术各个领域的影响始于合成具有明确表面的明确纳米尺寸物体（纳米粒子）的能力。 该研究项目旨在开发合成功能纳米颗粒的全新方法，这些纳米颗粒可以与蛋白质结合形成复杂材料或产生可观察的信号。 这种纳米颗粒可能会带来影响生物技术的多功能传感技术。