CAREER: Globular Macromolecules with Functionalized Interiors

杜兰大学化学系的先进材料项目将此奖项授予杜兰大学。有了这个职业奖，Sankaran Thayumanavan教授将研究大分子中的分子相互作用，并将设计功能和动态树状大分子的参数。具有疏水性和亲水性基团的树状大分子将被设计、合成和功能化，以在极性溶剂中提供亲水性外表面和在极性溶剂中提供亲水性外表面。这些研究将为设计具有功能实用性的大分子二阶结构的发展提供关键概念。有了这些树状大分子，就有可能在极性介质中将极性有机底物隔离到这些树状大分子内部，用于催化、相转移反应、药物输送系统和传感器。拟议中的教育拓展项目“杜兰科学学者项目”是一个强大的教育项目，该项目将使当地高中生接触到科学和工程项目。在其他教员的帮助下，该项目的联合主任PI将在秋季和春季学期为高中三年级和四年级学生提供化学、物理、细胞生物学、分子生物学、环境科学、化学工程、机械工程和生物医学工程课程。具有官能团的新型树状聚合物可用于极性和极性溶剂，在催化、相转移反应、药物传递系统和传感器等方面具有广泛的应用。拟议中的杜兰大学科学学者计划将向高中生展示科学和工程学科的不同方面，并将为他们在大学水平的科学和工程项目的高级学习做好准备。

The Advanced Materials Program in the Division of Chemistry makes this award to Tulane University. With this Career award, Professor Sankaran Thayumanavan will study molecular interactions in macromolecules, and will design parameters for functional and dynamic dendrimers. Dendrimers with both hydrophobic and hydrophilic groups will be designed, synthesized and functionalized to provide hydrophilic outer surfaces in polar solvents and hydrophilic outer surfaces in apolar solvents. The studies will provide key concepts for the development of designed second order structure in macromolecules with functional utility. With these dendrimers, it would be possible to sequester apolar organic substrates into these dendrimeric interiors in polar media for applications in catalysis, phase transfer reactions, drug delivery systems and sensors. The proposed educational outreach program 'Tulane Science Scholars Program is a strong educational program, and this program will expose local high school students to science and engineering programs. The PI, the Co-director of the program with the help of other faculty members, will be provide courses to high school juniors and seniors in Chemistry, Physics, Cell Biology, Molecular Biology, Environmental Sciences, Chemical Engineering, Mechanical Engineering and Biomedical Engineering during Fall and Spring semesters. New dendrimeric polymers with functional groups may be used in polar and apolar solvents with applications in catalysis, phase transfer reactions, drug delivery systems and sensors. The proposed Tulane Science Scholars Program will expose high school students in different aspects of science and engineering subjects, and will prepare them for advanced studies in science and engineering programs at college level.