Synthesis and self-assembly of glycomimetics

糖模拟物的合成和自组装

• 批准号: 1313633
• 负责人: Guijun Wang
• 金额: $ 37.5万
• 依托单位: Old Dominion University Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-10-25 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1313633&HistoricalAwards=false
• 关键词: Synthesis; self; assembly; glycomimetics

In this project funded by the Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division, the research group of Professor Guijun Wang of University of New Orleans designs and synthesizes novel classes of glycoconjugates and studies the formation of self-assembling systems from these carbohydrate-based molecular entities. Carbohydrates are abundant natural products and renewable resources on earth. This research aims to advance our understandings on the correlation between molecular structures and macroscopic properties of glycomimetics and to take advantage of the sustainable resource to yield biocompatible materials that have potential applications as light responsive materials or unique supramolecular architectures suitable as ligands for carbohydrate-binding proteins.Besides being food and energy sources, carbohydrates also play important roles in biological systems such as mediating signal transduction, cell growth and adhesion, etc. This research utilizes sustainable resource as the bases to form smart materials that are responsive to various stimuli including light and heat. The development of new synthetic methods for glycomimetics with desired functionality would enable the generation of novel systems that are potentially useful for biomedicines and biomaterials. The broader impact activities of this project also include outreach activities to expose children to a fun science atmosphere, internship opportunities at pharmaceutical companies, and the multidisciplinary research training of undergraduate and graduate students and postdoctoral researchers (including members of underrepresented groups).

在这个由化学学部大分子、超分子和纳米化学项目资助的项目中，美国新奥尔良大学王桂军教授的研究小组设计并合成了新型的糖缀合物，并研究了这些基于碳水化合物的分子实体自组装系统的形成。碳水化合物是地球上丰富的天然产物和可再生资源。本研究旨在促进我们对糖模拟物分子结构与宏观性质之间关系的理解，并利用可持续资源生产具有光响应材料或适合作为碳水化合物结合蛋白配体的独特超分子结构的生物相容性材料。碳水化合物除了作为食物和能量来源外，还在生物系统中发挥着重要作用，如介导信号转导、细胞生长和粘附等。本研究利用可持续资源作为基础，形成对各种刺激（包括光和热）有反应的智能材料。具有所需功能的糖仿制品的新合成方法的发展将使生物医学和生物材料的潜在有用的新系统的产生成为可能。该项目更广泛的影响活动还包括让孩子们接触有趣的科学氛围的外展活动，制药公司的实习机会，以及本科生、研究生和博士后研究人员（包括代表性不足的群体成员）的多学科研究培训。