Carbohydrate Based Self Assembling Systems

基于碳水化合物的自组装系统

• 批准号: 0518283
• 负责人: Guijun Wang
• 金额: --
• 依托单位: University of New Orleans
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0518283&HistoricalAwards=false
• 关键词: Carbohydrate; Based; Self; Assembling; Systems

The main focus of this research project is to create novel functional biocompatible materials from abundant carbohydrates that could lead to advancements in carbohydrate chemistry, materials science, biotechnology, and the biomedical field. This program will allow the discovery of novel materials with desired functionality based on renewable resources. Professor Wang's research will increase the availability of small molecule hydrogelators and allow others to explore their applications. The immobilization of enzymes using the hydrogelators obtained is important for biocatalysis, high throughput assays, and drug discovery. Diacetylene-containing hydrogelators can form stimuli-responsive smart gels that can be used as sensors for pH, temperature, and for sensing the presences of biomolecules and toxins. The new materials discovered will have biomedical applications as controlled release media, tissue-engineering scaffolds, and also for protein immobilization and purification. This will advance understanding of the correlation of molecular structures and macroscopic properties and help to guide other researchers in designing intelligent materials.The Organic and Macromolecular Chemistry Program supports Professor Guijun Wang of the University of New Orleans whose research involves several interdisciplinary research areas including organic synthesis, supramolecular chemistry, bioorganic chemistry and materials science. The broader impacts of the proposed work in addition to the potential biomedical applications are the training of students at all levels and the incorporation of this research into education. The training of students in these multidisciplinary areas will prepare them for future careers in biomaterials research, organic synthesis, and biomedical fields. Special efforts will be made to recruit undergraduate students, especially minorities, to conduct research, which can help to improve retention and stimulate interest in science fields. A website will be developed containing related scientific discoveries, background information, and career guidance for students. A planned future special topics course resulting from the current research and planned international collaborations will further increase the impact of this research program.

该研究项目的主要重点是从丰富的碳水化合物中创造新型功能性生物相容性材料，从而推动碳水化合物化学，材料科学，生物技术和生物医学领域的进步。该计划将允许基于可再生资源发现具有所需功能的新材料。王教授的研究将增加小分子水凝胶剂的可用性，并允许其他人探索其应用。使用所获得的水凝胶因子固定化酶对于生物催化、高通量测定和药物发现是重要的。含二乙炔的水凝胶因子可以形成刺激响应性智能凝胶，其可以用作pH、温度的传感器，以及用于感测生物分子和毒素的存在。新材料的发现将有生物医学应用作为控制释放介质，组织工程支架，也用于蛋白质固定和纯化。有机与高分子化学项目支持美国新奥尔良大学的王桂君教授，他的研究涉及有机合成、超分子化学、生物有机化学和材料科学等多个跨学科研究领域。除了潜在的生物医学应用外，拟议工作的更广泛影响是培训各级学生并将这项研究纳入教育。学生在这些多学科领域的培训将为他们在生物材料研究，有机合成和生物医学领域的未来职业生涯做好准备。将作出特别努力，招收本科生，特别是少数民族学生从事研究，这有助于提高保留率，激发对科学领域的兴趣。将开发一个网站，包含相关的科学发现，背景信息和学生的职业指导。根据目前的研究和计划中的国际合作，计划中的未来专题课程将进一步增加这项研究计划的影响。