CONFERENCE: 2013 FASEB Conference on Genetic Recombination and Genome Rearrangements to be held July 21-26, 2013 in Steamboat Springs, CO

智力优势：美国实验生物学学会联合会（FASEB）关于遗传修饰和基因组重排的会议将于2013年7月21日至26日在科罗拉多的汽船泉举行。基因重组在塑造基因组结构和维持所有生物体的基因组完整性方面起着关键作用。DNA损伤可由环境因素或内源性过程产生，最显著的是由染色体复制期间的错误和机械故障引起。同源和非同源的基因重组修复了这种损伤。这些修复事件有可能造成遗传变化，而由不准确的修复引起的染色体重排通常与向癌症的转变有关。对于有性生殖，同源重组确保减数分裂期间染色体正确分离并产生遗传多样性。程序性染色体重排在免疫系统细胞以及致病微生物中产生多样性。虽然在理解遗传重组的机制和生物后果方面取得了相当大的进展，但关于这一基本生物过程的基本机制和调节仍有许多东西需要了解，会议致力于实现这一目标的进展。主题包括生物化学和重组机制，真核生物和原核生物中复制、修复和重组之间的联系，减数分裂，基因组重排和进化，以及基因组完整性的维护。更广泛的影响：任何科学领域的进步都是通过研究人员之间的交流来促进的，这是会议的一个重要目标。它将聚集大约200名研究人员，他们在一系列生物系统中使用不同的实验方法研究重组的各个方面。所有与会者提供平台或海报介绍，涵盖新的和未发表的工作，并有充分的机会进行讨论，从所有参与者。一本摘要书将提供摘要和与会者联系信息，以促进会议时间范围以外的互动。要取得进展，还需要吸收新领域的研究人员。特别努力让年轻调查员和代表性不足群体的成员，包括妇女参加;对许多人来说，这将是他们第一次有机会发言。为了进一步促进这一目标，六分之一的平台位置被分配给从摘要中选出的演讲，预计将针对年轻的研究人员。“会见专家”会议致力于促进演讲者和其他与会者，特别是研究生和博士后之间的互动。此外，将利用旅行奖学金鼓励年轻调查员、受训人员和任职人数不足群体的成员参加。

Intellectual Merit: The Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements will be held July 21-26, 2013 in Steamboat Springs, Colorado. Genetic recombination plays a key role in molding genome structure and maintaining genome integrity in all organisms. DNA damage can be produced by environmental agents or by endogenous processes, most notably by errors and mechanistic failure during chromosome replication. Genetic recombination, both homologous and non-homologous, repairs this damage. These repair events have the potential to create genetic change, and chromosome rearrangements caused by inaccurate repair are often associated with the transition to cancer. For sexual reproduction, homologous recombination ensures proper chromosome disjunction during meiosis and generates genetic diversity. Programmed chromosomal rearrangements generate diversity in cells of the immune system, as well as in disease-causing microorganisms. While considerable progress has been made in understanding the mechanisms and biological consequences of genetic recombination, much remains to be learned regarding the underlying mechanisms and regulation of this fundamental biological process, and the conference is devoted to progress towards this goal. Topics to be covered include biochemistry and mechanisms of recombination, connections between replication, repair and recombination in eukaryotes and prokaryotes, meiosis, genome rearrangements and evolution, and maintenance of genome integrity. Broader Impacts: Progress in any scientific field is fostered by communication between researchers, and this is an important aim of the conference. It will assemble about 200 investigators who study diverse aspects of recombination, in a range of biological systems and with different experimental approaches. All attendees give platform or poster presentations covering new and unpublished work, and there is ample opportunity for discussion from all participants. An abstract book will provide abstracts and participant contact information, to facilitate interaction beyond the time frame of the meeting. Progress also requires the incorporation of researchers who are new to a field. Special efforts are made to include young investigators and members of underrepresented groups, including women; for many, this will be their first opportunity to present. To further promote this goal, one in six platform slots are allocated to talks selected from abstracts, and are expected to be directed to young investigators. A "Meet the Experts" session is dedicated to fostering interaction between speakers and other attendees, especially graduate students and postdocs. In addition, travel scholarships will be used to encourage participation by young investigators, trainees and by members of underrepresented groups.