SBIR Phase I: Dynamic Infrared-imaging of Skin Cancer (DISC)

SBIR 第一阶段：皮肤癌动态红外成像 (DISC)

• 批准号: 1315372
• 负责人: Sanchita Krishna
• 金额: $ 14.99万
• 依托单位: SK Infrared LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1315372&HistoricalAwards=false
• 关键词: SBIR; Phase; Dynamic; Infrared; imaging

This Small Business Innovation Research Phase I Project proposes to develop a novel non-invasive diagnostic imaging tool for the early detection of skin cancer. In this project, a controlled temperature stimulus is applied to the suspected lesion and the thermal recovery process is captured with an Advanced Longwave Infrared-imaging and Analysis System (ALIAS) capable of measuring temperature differences 0.02°C. The underlying hypothesis of this approach is that the dynamic temperature response of malignant cells will be different from that of the surrounding normal skin cells due to heat generation caused by abnormal processes such as cell proliferation and thermal diffusion, increased metabolism and excess blood flow. The Phase I effort will involve a pilot study to develop a quantifiable metric to capture the differences in the temperature curves and investigate whether malignant lesions such as Basal Cell Carcinoma (BCC), Squamous Cell Carcinoma (SCC) and Malignant Melanoma (MM) can be distinguished from benign lesions using this metric.The broader impact/commercial potential of this project would be a dramatic reduction in savings to the US health care industry. For millions of people who observe a suspicious lesion on their skin, the only options available today in the dermatology clinic are either a subjective visual test or an invasive biopsy. Since doctors perform biopsies on any clinically atypical lesions to minimize risk, the ratio of benign lesions biopsied to confirmed melanomas is 80 to 1. There is a need for a real-time, non-invasive, pain-free technology that can bridge this gap. The proposed approach is based on a fundamental quantity associated with cancer growth, namely heat generation. Currently, we spend $10.8B/year on skin cancer biopsies in the US along with a project increase of 14% increase annually. If this approach is successful and the number of biopsies can be decreased by a factor of two, it would represent a $5.4B savings to the US health care industry. The NSF SBIR funding will provide a critical bridge funding that will enable the reduction of technological risk to solicit commercial venture capitalist funding.

这个小企业创新研究第一阶段项目提出开发一种新的非侵入性诊断成像工具，用于早期检测皮肤癌。 在该项目中，将受控温度刺激应用于疑似病变，并使用能够测量0.02°C温差的高级长波红外成像和分析系统（ALIAS）捕获热恢复过程。这种方法的基本假设是，恶性细胞的动态温度响应将不同于周围正常皮肤细胞的动态温度响应，这是由于异常过程（例如细胞增殖和热扩散、代谢增加和过量血流）引起的热量产生。第一阶段的工作将涉及一项试点研究，以开发一种可量化的指标，以捕捉温度曲线的差异，并调查恶性病变，如基底细胞癌（BCC），鳞状细胞癌（SCC）和恶性黑色素瘤（MM）可以使用该指标与良性病变区分开。该项目的商业潜力将大大减少美国医疗保健行业的储蓄。对于数百万在皮肤上观察到可疑病变的人来说，今天在皮肤科诊所唯一可用的选择是主观视觉测试或侵入性活检。由于医生对任何临床上不典型的病变进行活检，以尽量减少风险，活检的良性病变与确诊的黑色素瘤的比例是80比1。需要一种实时、无创、无痛的技术来弥补这一差距。所提出的方法是基于与癌症生长相关的基本量，即产热。目前，我们在美国每年花费108亿美元用于皮肤癌活检，沿着每年增加14%。如果这种方法成功，活检的数量可以减少两倍，这将为美国医疗保健行业节省54亿美元。NSF SBIR资金将提供一个关键的桥梁资金，这将有助于降低技术风险，以吸引商业风险资本家的资金。