SBIR Phase I: Feasibility of Dynamic Configurable Liquid Molding

SBIR 第一阶段：动态可配置液体成型的可行性

• 批准号: 2052113
• 负责人: Eleanor Derbyshire
• 金额: $ 25.6万
• 依托单位: Hummingbird Nano, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2021-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2052113&HistoricalAwards=false
• 关键词: SBIR; Phase; Feasibility; Dynamic; Configurable

The broader impact/ commercial potential of this SBIR Phase I project is the creation of a new set of tools for bioscience applications. The innovation has shown promise in benchtop tests to fill a capability gap in manufacturing, and the project will build upon this promise to create 3-dimensional nanoscale fluid pathways. The first target application is to enable widespread use of nanometer-sized particles (30-150 nm) to carry cell signaling information throughout the body. Particles designed to signal a particular cellular response are a major component of drug therapeutics as their size allows them to access parts of the body otherwise impossible to reach, such as the blood-brain barrier in the event of a stroke and tumor penetration for cancer patients. Problematic for these research endeavors is the differentiating these particles from others due to similarity in size (100-300 nm). The innovation could enable these nanoscale entities to traverse nanoscale pathways, resulting in size and physics-based exclusion from other particles. Success in this project aids in promoting the advancement of detection and treatment for global health issues, adding to the general welfare of society, as well as creating a new sector in U.S. bioeconomy.Phase I assesses the feasibility of a potentially disruptive new manufacturing process to create a solid form structure with 3-dimensional pathways, such as helices and sine waves, of circular cross section interior channels for use in micro/nano-fluidics products. The innovation uses the physics of fluid flow to dynamically mold a fluid against a smart fluid, during which process the diameter of the channel being formed can be changed by adjusting the process variables in real-time. The work progresses the knowledge associated with advancing manufacturing capabilities and enables a wide variety of fields based on the products made using the method. For the former, the technology provides a new way to rapidly create fluidic pathways for nano to micro structures, enhancing the understanding of fluidic behaviors, polymerization, smart fluid applications, and creates a new field of study for the dynamic behavior of fluid/fluid molding. The technical goals of the Phase I work use a combination of fluidic modeling and the set-up and execution of a series of experimental tests to demonstrate active control of the channel diameter for 50-500 nm, 3-dimensional structures with controlled diameter channels, and merging and diverging channels.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

SBIR第一阶段项目的更广泛的影响/商业潜力是为生物科学应用创建一套新的工具。这项创新在实验室测试中显示出了填补制造能力空白的希望，该项目将在此基础上创建三维纳米级流体通道。第一个目标应用是使纳米尺寸的颗粒（30-150 nm）能够广泛使用，以在整个身体中携带细胞信号信息。设计用于发出特定细胞反应信号的颗粒是药物治疗的主要组成部分，因为它们的大小允许它们进入身体的其他部位，否则无法到达，例如在中风和癌症患者肿瘤穿透的情况下的血脑屏障。这些研究努力的问题是由于尺寸相似（100-300 nm）而将这些颗粒与其他颗粒区分开。这项创新可以使这些纳米级实体能够穿越纳米级路径，从而导致基于尺寸和物理的排斥其他粒子。该项目的成功有助于促进全球健康问题的检测和治疗的进步，增加社会的普遍福利，并在美国创造一个新的部门生物经济。第一阶段评估了一种潜在的破坏性新制造工艺的可行性，以创造一种具有三维路径的固体形式结构，如螺旋和正弦波，用于微/纳米流体产品的圆形横截面内部通道。该创新使用流体流动的物理学来动态地对智能流体进行流体模制，在此过程中，可以通过实时调整过程变量来改变正在形成的通道的直径。这项工作推进了与先进制造能力相关的知识，并基于使用该方法制造的产品实现了各种各样的领域。对于前者，该技术提供了一种新的方法来快速创建纳米到微米结构的流体通道，增强了对流体行为，聚合，智能流体应用的理解，并为流体/流体成型的动态行为创造了一个新的研究领域。阶段I工作的技术目标使用流体建模和一系列实验测试的设置和执行的组合，以证明具有受控直径通道的50-500 nm、3维结构的通道直径的主动控制，该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准。