NSF East Asia and Pacific Summer Institute (EAPSI) for FY 2013 in Singapore

2013 财年 NSF 东亚及太平洋地区暑期学院 (EAPSI) 在新加坡举行

• 批准号: 1316886
• 负责人: Kenneth Yancey
• 金额: $ 0.51万
• 依托单位: Yancey Kenneth G
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1316886&HistoricalAwards=false
• 关键词: NSF; East; Asia; Pacific; Summer

This action funds Kenneth Gene Yancey of Cornell University to conduct a research project in Engineering during the summer of 2013 at The National University of Singapore in Singapore. The project title is "Simultaneous Detection of Cancer and TB using DNA-based Nanobarcodes in a Portable Device for In-home Diagnostics." The host scientist is Dr. Jackie Ying.Every year, the World Health Organization reports that 1 in 4 people in the United States will die of cancer and that one third of the world population has tuberculosis (TB). Early detection reduces the incidence and fatal potential of cancer and highly transmittable diseases like TB. To address this, we are developing tree-like DNA nanobarcodes which use a unique ratio of fluorescent tags to detect multiple disease simultaneously. Already these barcodes are demonstrating multiplexed attomole detection using the specificity of DNA hybridization and the sensitivity of fluorescence. In the course of this EAPSI project, this system is being improved by applying it to real DNA samples and integrating it in a microfluidic device for the detection of disease anywhere in the world.Broader impacts of an EAPSI fellowship include providing the Fellow a first-hand research experience outside the U.S.; an introduction to the science, science policy, and scientific infrastructure of the respective location; and an orientation to the society, culture and language. These activities meet the NSF goal to educate for international collaborations early in the career of its scientists, engineers, and educators, thus ensuring a globally aware U.S. scientific workforce. Furthermore, this EAPSI project is not only potentially developing better methods for the DNA-based detection of new diseases, but also promoting outreach to students of all ages and disciplines. Several undergraduate students are involved with this project and results will be disseminate using a series of Youtube videos and apps designed to engage the community. The host location is ideal for accomplishing EAPSI's goal of fostering international exposure of U.S. graduate students due to the NUS' highly collaborative environment consisting of numerous academic, industrial and clinical collaborations.

这项行动为康奈尔大学的肯尼思·吉恩·扬西（Kenneth Gene Yancey）提供了资金，于2013年夏季在新加坡国立大学在新加坡国立大学进行工程研究项目。 该项目的标题是“使用基于DNA的纳米骨架在便携式设备中用于室内诊断的同时检测癌症和结核病”。主持人科学家是杰基·伊宁（Jackie Ying）博士。每一年，世界卫生组织报告说，美国四分之一的人将死于癌症，而世界三分之一的人口患有结核病（TB）。早期检测会降低癌症的发病率和致命潜力以及TB等高度可传播疾病。为了解决这个问题，我们正在开发类似树状的DNA纳米骨架，这些DNA纳米骨架使用荧光标签的独特比率同时检测多种疾病。这些条形码已经在使用DNA杂交的特异性和荧光灵敏度证明了多路复用的Attomole检测。在这个EAPSI项目的过程中，将该系统应用于实际DNA样本并将其集成到微流体设备中，以检测世界上任何地方的疾病。各自位置的科学，科学政策和科学基础设施的简介；以及社会，文化和语言的方向。 这些活动符合NSF的目标，以在其科学家，工程师和教育工作者的职业生涯的早期对国际合作进行教育，从而确保全球意识的美国科学劳动力。 此外，这个EAPSI项目不仅有可能为基于DNA的新疾病的检测提供更好的方法，而且还可以促进对所有年龄和学科的学生的推广。几位本科生参与了该项目，结果将使用一系列旨在吸引社区的YouTube视频和应用程序进行传播。主机位置非常适合实现EAPSI的目标，即由于NUS的高度协作环境包括众多学术，工业和临床合作，促进美国研究生的国际曝光率。