NSF East Asia and Pacific Summer Institute (EAPSI) for FY 2013 in Australia

2013 财年 NSF 东亚及太平洋地区暑期学院 (EAPSI) 在澳大利亚举行

• 批准号: 1316907
• 负责人: Christina Forbes
• 金额: $ 0.51万
• 依托单位: Forbes Christina R
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1316907&HistoricalAwards=false
• 关键词: NSF; East; Asia; Pacific; Summer

This action funds Christina Forbes of the University of Delaware to conduct a research project in the Mathematical and Physical Sciences area during the summer of 2013 at the University of Queensland in St. Lucia, Queensland, Australia. The project title is "Synthetic Modifications to the Cyclic Protein Kalata B1." The host scientist is Dr. David Craik.Cyclic peptides (cyclotides) are small proteins with a continuous circular backbone, forming a structure that is resistant to thermal and enzymatic degradation. Kalata B1 is a plant-derived cyclotide woven with three disulfide bonds, creating an exceptionally stable structure with anti-HIV activity. Due to its short sequence, there are few sites for functionalization in Kalata B1 that do not change its core structural stability. This project broadens the potential applications of Kalata B1 by incorporating non-natural amino acids with bioorthogonal chemical "handles," generating a uniquely versatile and stable platform for molecular scaffolding. These integrated "handles" can be further modified to decorate synthetic Kalata B1 with small molecules, materials, and proteins for applications in materials science and small molecule library screening.Broader impacts of an EAPSI fellowship include providing the Fellow a first-hand research experience outside the U.S.; an introduction to the science, science policy, and scientific infrastructure of the respective location; and an orientation to the society, culture and language. These activities meet the NSF goal to educate for international collaborations early in the career of its scientists, engineers, and educators, thus ensuring a globally aware U.S. scientific workforce. Furthermore, this fellowship will establish an international, interdisciplinary collaboration based on the design, synthesis, and applications of modifiable cyclotides for biomolecular scaffolding. On completion of this work, the results will be published in a peer-reviewed journal so that other researchers may use cyclotide scaffolds in new applications.

这项行动为特拉华大学的克里斯蒂娜·福布斯（Christina Forbes）提供了2013年夏季在澳大利亚昆士兰州圣卢西亚大学的数学和物理科学领域进行研究项目。 项目标题是“对环状蛋白Kalata B1的合成修饰”。宿主科学家是戴维·克雷克（David Craik）博士。环球肽（旋风）是带有连续圆形主链的小蛋白质，形成了一种对热和酶促降解具有抗性的结构。 Kalata B1是一种具有三个二硫键的植物衍生的环肽，创造了具有抗HIV活性的异常稳定的结构。由于其短序列，在Kalata B1中很少有功能化的位点不会改变其核心结构稳定性。该项目通过将非天然氨基酸与生物正交化学“手柄”结合在一起，扩大了Kalata B1的潜在应用，从而生成了一个独特的通用和稳定的平台，用于分子脚手架。可以进一步修改这些集成的“手柄”，以用小分子，材料和蛋白质用于材料科学和小分子库筛选中的合成Kalata B1。各自位置的科学，科学政策和科学基础设施的简介；以及社会，文化和语言的方向。 这些活动符合NSF的目标，以在其科学家，工程师和教育工作者的职业生涯的早期对国际合作进行教育，从而确保全球意识的美国科学劳动力。 此外，该奖学金将基于可修改的循环剂在生物分子脚手架上的设计，合成和应用，建立国际，跨学科的合作。完成这项工作后，结果将在经过同行评审的期刊上发布，以便其他研究人员可以在新应用程序中使用旋风型脚手架。