Cerebral network dysfunction in patients with hepatic encephalopathy (B07)

目前肝性脑病（HE）的病理生理学概念假设大脑网络的改变导致HE的临床不同的运动、认知和感觉症状。为了更好地了解这些网络改变的机制，我们将对HE患者进行神经生理学研究（TMS-EEG、MEG）和MR谱，以深入了解gabaergy和glutamergy神经传递的体内变化，以及氨、神经递质和其他神经代谢物的脑区含量

The current pathophysiological concept of hepatic encephalopathy (HE) postulates that alterations of cerebral networks lead to the clinically diverse motor, cognitive and sensory symptoms of HE. In order to better understand the mechanisms of these network alterations, neurophysiological investigations (TMS-EEG, MEG) and MR spectroscopy will be performed in patients with HE to provide insights into in vivo changes of GABAergic and glutamatergic neurotransmission as well as the regional cerebral content of ammonia, neurotransmitters and other neurometabolites