Cerebral network dysfunction in patients with hepatic encephalopathy (B07)

肝性脑病患者的脑网络功能障碍（B07）

• 批准号: 211926324
• 金额: --
• 依托单位: Institut für Klinische Neurowissenschaften und Medizinische Psychologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/211926324?language=en
• 关键词: Cerebral; network; dysfunction; patients; hepatic

The current pathophysiological concept of hepatic encephalopathy (HE) postulates that alterations of cerebral networks lead to the clinically diverse motor, cognitive and sensory symptoms of HE. In order to better understand the mechanisms of these network alterations, neurophysiological investigations (TMS-EEG, MEG) and MR spectroscopy will be performed in patients with HE to provide insights into in vivo changes of GABAergic and glutamatergic neurotransmission as well as the regional cerebral content of ammonia, neurotransmitters and other neurometabolites

目前肝性脑病(HE)的病理生理学概念假定大脑网络的改变导致临床上不同的HE的运动、认知和感觉症状。为了更好地了解这些网络改变的机制，将对HE患者进行神经生理学检查(TMS-EEG，MEG)和磁共振波谱检查，以深入了解GABA能和谷氨酸能神经传递的体内变化以及大脑局部氨、神经递质和其他神经代谢物的含量