Collaborative Research: SI2-SSI: A Sustainable Open Source Software Pipeline for Patient Specific Blood Flow Simulation and Analysis

合作研究：SI2-SSI：用于患者特定血流模拟和分析的可持续开源软件管道

• 批准号: 1339841
• 负责人: Shawn Shadden
• 金额: $ 30.63万
• 依托单位: Illinois Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1339841&HistoricalAwards=false
• 关键词: Collaborative; Research; SI2; SSI; Sustainable

The SimVascular package is a crucial research tool for cardiovascular modeling and simulation, and has contributed to numerous advances in personalized medicine, surgical planning and medical device design. SimVascular is currently the only comprehensive software package that provides a complete pipeline from medical image data segmentation to patient specific blood flow simulation and analysis. This software now forms the backbone in cardiovascular simulation research in a small but active group of domestic and international academic labs. However, since its original release there have been several critical barriers preventing wider adoption by new users, application to large-scale research studies, and educational access. These include 1) the cost and complications associated with embedded commercial components, 2) the need for more efficient geometric model construction tools, 3) lack of sustainable architecture and infrastructure, and 4) a lack of organized maintenance. This project is addressing the above roadblocks through the following aims: 1) create a sustainable and modular open source SimVascular 2.0 project housed at Stanford Simbios? simtk.org, with documentation, benchmarking and test suites, 2) provide alternatives to all commercial components in the first truly open source release of SimVascular, 3) improve the image segmentation methods and efficiency of model construction to enable high-throughput studies, and 4) enhance functionality by merging state of the art research in optimization, flow analysis, and multiscale modeling. The project leverages existing resources and infrastructure at simtk.org, and builds upon the significant previous investment that enabled the initial open source release of SimVascular. Access is further enhanced by cross-linking with the NIH funded Vascular Model Repository. This project will increase the user base and build a sustainable software platform supported by an active open source community. Releasing the first fully open source version of SimVascular will enable greater advances in cardiovascular medicine, provide open access to state of the art simulation tools for educational purposes, and facilitate training of young investigators. These efforts will also further promote diversity and attract students to science and engineering by leveraging this software to enable high school field trips to the UCSD StarCAVE to view simulation data using virtual reality.

SimVascular软件包是心血管建模和仿真的重要研究工具，为个性化医疗、手术规划和医疗器械设计方面的许多进步做出了贡献。SimVascular是目前唯一一个提供从医学图像数据分割到患者特定血流模拟和分析的完整管道的综合软件包。该软件现已成为国内和国际学术实验室中一个小型但活跃的团队的心血管模拟研究的支柱。然而，自其最初发布以来，有几个关键障碍阻碍了新用户的广泛采用，大规模研究的应用和教育机会。这些问题包括：1）与嵌入式商业组件相关的成本和复杂性，2）需要更有效的几何模型构建工具，3）缺乏可持续的架构和基础设施，以及4）缺乏有组织的维护。该项目通过以下目标解决上述障碍：1）创建一个位于斯坦福大学Simbios的可持续和模块化开源SimVascular 2.0项目。simtk.org，提供文档、基准测试和测试套件，2）在SimVascular的第一个真正开源版本中提供所有商业组件的替代品，3）改进图像分割方法和模型构建效率，以实现高通量研究，以及4）通过合并优化、流动分析和多尺度建模方面的最新研究来增强功能。该项目利用了simtk.org上的现有资源和基础设施，并建立在之前的重大投资基础上，这些投资使SimVascular的初始开源版本得以实现。通过与NIH资助的血管模型库的交叉链接，进一步增强了访问权限。该项目将增加用户基础，并建立一个由活跃的开源社区支持的可持续软件平台。 SimVascular的第一个完全开源版本的发布将使心血管医学取得更大的进步，为教育目的提供最先进的模拟工具的开放访问，并促进年轻研究人员的培训。这些努力还将进一步促进多样性，并通过利用该软件吸引学生到科学和工程，使高中实地考察到UCSD StarCAVE使用虚拟现实查看模拟数据。