CAREER: Hemodynamic processes in thrombosis

1150947Shadden 血流改变引起的不适当凝血（血栓形成）是几乎所有主要心血管疾病、手术和设备的主要关注点。从概念上讲，血流以两种一般方式影响血栓形成：通过施加力和引导运输。 然而，对这些过程的机械理解仍然不明确。这一直是解决为什么某些血流特征与血栓事件有利或不利相关的关键障碍。该项目的目标是开发所需的工具和见解，以确定血流局部扰动增强病理性血栓形成的机制。这将通过计算血流建模和分析的进步以及收集的经验数据来帮助指导和验证数值结果来实现。这项工作将专门解决血流改变如何导致狭窄动脉中血栓形成，这是心脏病发作和中风的主要原因。最近的结果揭示了流体力和运输机制之间惊人的协同相互作用，这与狭窄血栓的临床观察结果一致。使用该项目开发的工具和见解来解决哪些血流动力学条件是重要的，以及如何最好地建模、识别和传达它们，具有更广泛的潜力。该项目将促进特别适合 PI 环境的几个方面的教育。伊利诺伊理工学院 (IIT) 数学和科学教育部门将把重要的发现和技术整合到正在进行的 STEM 课程开发中，以向 K-5 学生推广工程学，并整合到面向芝加哥高中学生的 IIT 波音学者学院计划中。用于支持这项研究的实验模型的设计、制造和测试将纳入 IIT 独特的跨专业项目计划，由 PI 指导。

1150947ShaddenInappropriate clotting (thrombosis) stemming from alterations in blood flow is a primary concern with nearly all major cardiovascular diseases, surgeries, and devices. Conceptually, blood flow influences thrombosis in two general ways: by imparting forces and directing transport. However, mechanistic understandings of these processes remain poorly defined. This has been a critical barrier in addressing why certain flow features correlate favorably, or unfavorably, to thrombotic events.The objective of this project is to develop tools and insights needed to determine the mechanisms by which local disturbances in blood flow potentiate pathological clot formation. This will be accomplished through advancements in computational blood flow modeling and analysis, along with empirical data collected to help guide and validate the numerical findings. This work will specifically address how altered flow leads to thrombus formation in stenotic arteries, which is the primary cause of heart attack and stroke. Recent results have uncovered striking and synergistic interactions between fluid forces and transport mechanisms that are consistent with clinical observations of stenotic thrombus. There is substantial broader potential to use the tools and insights developed by this project to address what hemodynamic conditions are important, and how they are best modeled, identified and conveyed.This project will foster education on several fronts uniquely suited to PI's environment. Important findings and techniques will be integrated by the Illinois Institute of Technology (IIT) Mathematics and Science Education department into ongoing STEM curriculum development to promote engineering to K-5 students, and into the IIT Boeing Scholars Academy Program for Chicagoland high school students. The design, fabrication and testing of experimental models used to support this research will be incorporated into IIT's unique Interprofessional Projects Program, instructed by the PI.