CAREER: Hemodynamic processes in thrombosis

职业：血栓形成的血流动力学过程

• 批准号: 1354541
• 负责人: Shawn Shadden
• 金额: $ 40万
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1354541&HistoricalAwards=false
• 关键词: CAREER; Hemodynamic; processes; thrombosis

1150947ShaddenInappropriate clotting (thrombosis) stemming from alterations in blood flow is a primary concern with nearly all major cardiovascular diseases, surgeries, and devices. Conceptually, blood flow influences thrombosis in two general ways: by imparting forces and directing transport. However, mechanistic understandings of these processes remain poorly defined. This has been a critical barrier in addressing why certain flow features correlate favorably, or unfavorably, to thrombotic events.The objective of this project is to develop tools and insights needed to determine the mechanisms by which local disturbances in blood flow potentiate pathological clot formation. This will be accomplished through advancements in computational blood flow modeling and analysis, along with empirical data collected to help guide and validate the numerical findings. This work will specifically address how altered flow leads to thrombus formation in stenotic arteries, which is the primary cause of heart attack and stroke. Recent results have uncovered striking and synergistic interactions between fluid forces and transport mechanisms that are consistent with clinical observations of stenotic thrombus. There is substantial broader potential to use the tools and insights developed by this project to address what hemodynamic conditions are important, and how they are best modeled, identified and conveyed.This project will foster education on several fronts uniquely suited to PI's environment. Important findings and techniques will be integrated by the Illinois Institute of Technology (IIT) Mathematics and Science Education department into ongoing STEM curriculum development to promote engineering to K-5 students, and into the IIT Boeing Scholars Academy Program for Chicagoland high school students. The design, fabrication and testing of experimental models used to support this research will be incorporated into IIT's unique Interprofessional Projects Program, instructed by the PI.

1150947由血流改变引起的不适当的凝血(血栓形成)是几乎所有主要心血管疾病、手术和设备的主要问题。从概念上讲，血流通过两种一般方式影响血栓形成：传递力量和引导运输。然而，对这些过程的机械性理解仍然很模糊。这一直是解决为什么某些血流特征与血栓事件有利或不利相关的关键障碍。该项目的目标是开发所需的工具和见解，以确定局部血流障碍增强病理性血栓形成的机制。这将通过计算血流建模和分析方面的进步以及收集的经验数据来实现，以帮助指导和验证数值结果。这项工作将专门研究血流改变如何导致狭窄动脉中血栓的形成，这是心脏病发作和中风的主要原因。最近的结果揭示了流体作用力和传输机制之间的显著和协同的相互作用，这与狭窄血栓的临床观察一致。使用这个项目开发的工具和洞察力来解决哪些血液动力学状况是重要的，以及如何最好地对它们进行建模、识别和传达，具有非常广泛的潜力。这个项目将在几个方面促进专门适合PI环境的教育。重要的发现和技术将由伊利诺伊理工学院(IIT)数学和科学教育部门整合到正在进行的STEM课程开发中，以向K-5学生推广工程学，并整合到IIT针对芝加哥高中生的波音学者学院计划中。用于支持这项研究的实验模型的设计、制造和测试将被纳入IIT独特的跨专业项目计划，由PI指导。