Conference: GRC Protein Folding Dynamics: From the Computer to the Cell: Protein Folding, Function and Evolution to be held in Galveston, TX on January 5-10, 2014

知识价值：关于蛋白质折叠动力学的戈登研究会议（GRC）“从计算机到细胞：蛋白质折叠、功能和进化”将于2014年1月5日至10日在德克萨斯州加尔维斯顿的加尔维斯酒店举行。会议将聚集实验学家和理论家讨论蛋白质折叠动力学及其在功能，蛋白质序列进化和蛋白质错误折叠相关疾病中的作用的基本问题。越来越清楚的是，了解蛋白质折叠动力学的细节对于描述几乎所有生命过程至关重要，包括蛋白质合成、共翻译折叠、蛋白质变构、蛋白质功能和与蛋白质错误折叠相关的疾病。本次会议将汇集资深科学家、博士后研究人员和研究生，他们来自蛋白质折叠动力学的广泛兴趣和方法。会议的性质允许参与者之间的密切互动，他们可以分享他们的想法和结果，无论是未发表的还是已发表的，无论是正式的还是非正式的。2014年的会议首次扩大到包括膜蛋白折叠和细胞内折叠以及蛋白质设计的完整正式会议。这次扩展主要是应前几年与会者的要求，目前的组织者认为扩大主题范围将增加会议的智力价值。更广泛的影响：通过将来自化学、物理和生物学的研究人员聚集在一起，在一个具体的论坛上探索该领域最近令人兴奋的发展，鼓励研究不同系统的研究人员进行公开讨论，加强了跨学科研究的新范式。该计划涵盖了一系列主题，不限于体外和体内折叠，蛋白质聚集，蛋白质进化和设计，以及蛋白质动力学在功能中的作用。将特别注意纳入种族、性别、年龄和地理位置的多样性。

Intellectual Merit:The Gordon Research Conference (GRC) on Protein Folding Dynamics "From the Computer to the Cell: Protein Folding, Function and Evolution" will be held at the Hotel Galvez in Galveston, Texas, January 5-10, 2014. The conference will assemble experimentalists and theoreticians to discuss basic issues in protein folding dynamics and their role in function, in the evolution of protein sequences and in disorders associated with protein misfolding. It has become increasingly clear that understanding the details of Protein Folding Dynamics is crucial in describing virtually all processes of life, including protein synthesis, co-translational folding, protein allostery, protein function and diseases related to protein misfolding. This meeting will bring together senior scientists, postdoctoral researchers and graduate students from a wide range of interests and approaches to protein folding dynamics. The nature of the conference allows close interaction among participants, who can share their ideas and results unpublished and published, officially and off-the-record. For the first time, the 2014 conference is expanding to include complete formal sessions on membrane protein folding and folding within the cell and protein design. This expansion is largely in response to requests from previous years' participants and current organizers believed that extending the range of topics would add to the intellectual merit of the conference.Broader Impacts:By bringing together researchers from chemistry, physics and biology to explore recent exciting developments in this field in a concrete forum that encourages open discussions from researchers working on different systems, the new paradigm of cross-disciplinary research is strengthened. The program covers a range of topics, not restricted to, in vitro and in vivo folding, protein aggregation, protein evolution and design, and the role of protein dynamics in function. Particular care will be taken for the inclusion of diversity in ethnicity, gender and age and geographical location.