EAGER: Fluorescence Studies of Surface Micro-heterogeneity in Thermoacidophile Lipid Membranes

EAGER：嗜热嗜酸脂质膜表面微观异质性的荧光研究

• 批准号: 1350841
• 负责人: Parkson Chong
• 金额: $ 18.1万
• 依托单位: Temple University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1350841&HistoricalAwards=false
• 关键词: EAGER; Fluorescence; Studies; Surface; Micro

Abstract#1350841Chong, Parkson L.Stable liposomes have many potential uses in drug formulations (and even skin-care products). Liposomes that can withstand autoclaving are especially desirable for medical applications. The PI proposes to investigate highly stable bipolar membranes (liposomes) with fluorescent tags that probe membrane properties at different membrane depths or at different lateral positions. Specifically, he hypothesizes that there should be significant structural and functional heterogeneities along the membrane normal and in the plane of the membrane, which are of critical importance in understanding membrane structure-function relationship for these ultra-stable architectures.The results obtained from this research should enhance the understanding of lipid-protein interactions and solute permeation in archaeal membranes and will have profound implications in technological applications, such as extraordinarily stable lipid matrix for biosensors, light harvesting devices, and nanoparticles for targeted imaging and therapy.

摘要#1350841 Chong，Parkson L.稳定脂质体在药物制剂（甚至护肤品）中具有许多潜在用途。能够耐受高压灭菌的脂质体对于医学应用是特别期望的。PI建议研究具有荧光标记的高度稳定的双极膜（脂质体），该荧光标记可探测不同膜深度或不同横向位置的膜特性。具体地说，他假设沿着沿着膜法线和在膜平面内应该存在显著的结构和功能异质性，这对于理解这些超稳定结构的膜结构-功能关系至关重要。本研究所获得的结果将增强对脂质-古细菌膜中的蛋白质相互作用和溶质渗透，并将在技术应用中具有深远的意义，例如用于生物传感器的非常稳定的脂质基质，光捕获装置，以及用于靶向成像和治疗的纳米颗粒。