CAREER: Mechanism as a Driving Force in Gold(I) Catalyzed Alkyne Functionalizations
职业生涯:金(I)催化炔烃功能化的驱动力机制
基本信息
- 批准号:1352296
- 负责人:
- 金额:$ 65万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2021-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor Amanda C. Jones of Wake Forest University is investigating improving the efficiency of gold-based catalysts by examining the chemical mechanisms by which they act. Gold catalysts are powerful and environmentally friendly reagents that can be used for the production of pharmaceuticals and fine chemicals. The economic feasibility of their use, however, is dependent on the ability to use them in minimal quantities with maximum recycling. The mechanistic understanding being pursued by this project is crucial to achieving a high level of efficiency. Professor Jones is examining the distinct reactivity of organogold compounds and the ability of cationic gold complexes to mediate addition reactions, transmetalations, and rearrangements via gold carbenes. The unifying theme is the current gap in information about the formation and reactivity of alkyl gold (C(sp3)-Au) intermediates. The approach is two-pronged and incorporates first the synthesis of organogold compounds and gold coordination complexes, and second, kinetic studies on those structures to elucidate mechanisms and improve future design of catalytic reactions. Development of a rapid-injection NMR apparatus will contribute to these studies by opening up the window of obtainable kinetic data. The project provides training for undergraduate and graduate students who will learn to execute chemical and scientific methods, conduct responsible research, and think critically about reaction mechanisms. Professor Jones is also developing reading clubs as a way to encourage early and life-long engagement with science. By exposing community members and elementary school students to novels with scientific themes, as well as the prose or biographical writings of "dual personalities," individuals who have achieved success in supposedly disparate areas (scientist vs. writer, artist, musician, activist), Professor Jones is working to cultivate positive attitudes toward science. These efforts contribute a non-traditional element to the recruitment of students to scientific fields.
在这个由化学系化学催化项目资助的项目中,阿曼达C.维克森林大学的琼斯正在研究通过检验金基催化剂的化学作用机制来提高它们的效率。金催化剂是一种功能强大且环保的试剂,可用于药品和精细化学品的生产。然而,其使用的经济可行性取决于能否以最小数量使用并最大限度地回收利用。该项目所追求的机械理解对于实现高水平的效率至关重要。琼斯教授正在研究有机金化合物的独特反应性和阳离子金络合物介导加成反应,金属转移和通过金卡宾重排的能力。统一的主题是目前的差距,在信息的形成和反应性的烷基金(C(sp3)-Au)中间体。该方法是双管齐下的,并结合了第一有机金化合物和金配合物的合成,第二,这些结构的动力学研究,以阐明机制和改善未来的催化反应的设计。开发快速注射核磁共振装置将有助于这些研究,通过打开窗口获得动力学数据。该项目为本科生和研究生提供培训,他们将学习执行化学和科学方法,进行负责任的研究,并批判性地思考反应机制。琼斯教授还在发展阅读俱乐部,以此来鼓励早期和终身参与科学。通过让社区成员和小学生接触以科学为主题的小说,以及“双重人格”的散文或传记作品,在所谓的不同领域(科学家与作家,艺术家,音乐家,活动家)取得成功的个人,琼斯教授正在努力培养对科学的积极态度。 这些努力为科学领域招收学生提供了一种非传统因素。
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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Amanda Jones其他文献
Contemporary National Trends and Variations of Pelvic Lymph Node Dissection in Patients Undergoing Robot-Assisted Radical Prostatectomy.
接受机器人辅助根治性前列腺切除术的患者盆腔淋巴结清扫的当代国家趋势和变化。
- DOI:
10.1016/j.clgc.2021.01.005 - 发表时间:
2021 - 期刊:
- 影响因子:3.2
- 作者:
Leilei Xia;Bofeng Chen;Amanda Jones;Ruchika Talwar;R. Chelluri;Daniel J Lee;T. Guzzo - 通讯作者:
T. Guzzo
1151: What antenatal fetal surveillance parameters predict fetal demise in Down syndrome?
- DOI:
10.1016/j.ajog.2019.11.1163 - 发表时间:
2020-01-01 - 期刊:
- 影响因子:
- 作者:
Juliet Bishop;Amanda Jones;Clark Johnson;Ahizechukwu Eke;Angie Jelin;Karin Blakemore - 通讯作者:
Karin Blakemore
Effects of Sirolimus on Anti-SARS-CoV-2 Vaccination in Patients With Lymphangioleiomyomatosis
西罗莫司对淋巴管平滑肌瘤病患者抗严重急性呼吸综合征冠状病毒2(SARS-CoV-2)疫苗接种的影响
- DOI:
10.1016/j.chest.2023.09.014 - 发表时间:
2024-02-01 - 期刊:
- 影响因子:8.600
- 作者:
Tat’Yana Worthy;Amanda Jones;Bennett E. Yang;Hiroko Ishiwata-Endo;Nishant Gupta;Joel Moss - 通讯作者:
Joel Moss
Diagnostic tools like ANDROTEST have estimated a disease incidence of 10%–40% in men aged over 45 years and suggest that up to 60 million men in the United States, Europe and Japan suffer
ANDROTEST 等诊断工具估计 45 岁以上男性的患病率为 10%–40%,并表明美国、欧洲和日本有多达 6000 万男性患有此病
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
C. Coss;Amanda Jones;M. Hancock;M. Steiner;J. Dalton - 通讯作者:
J. Dalton
Understanding executive leaders' thinking about evaluative inquiry – an exploratory study
了解行政领导者对评价性探究的思考——一项探索性研究
- DOI:
- 发表时间:
2018 - 期刊:
- 影响因子:0
- 作者:
Amanda Jones - 通讯作者:
Amanda Jones
Amanda Jones的其他文献
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