Collaborative Research: The evolution of hair and fur: Proximate and ultimate mechanisms shaping primate pelage variation

合作研究：头发和皮毛的进化：塑造灵长类动物皮毛变异的直接和最终机制

• 批准号: 1354997
• 负责人: Jason Kamilar
• 金额: $ 5.73万
• 依托单位: Midwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1354997&HistoricalAwards=false
• 关键词: Collaborative; Research; evolution; hair; fur

This project examines how core physiological and evolutionary processes shape biological diversity. Elucidating how genetic changes and selection pressures result in trait variation is a central goal of biology, and key to this is identifying the links between genes, form and function, and how these can alter the fitness of individuals and the evolutionary success of species. Moreover, understanding why and how many cellular and body structures have evolved independently in different species can explain how evolution takes multiple routes to 'solve' the same problem. The biology of hair is an ideal system for studying these links between genetics, form and function. Hair is an anatomical trait that is shaped by both natural selection (e.g., providing camouflage against predators, protection from parasites, maintaining body temperature in cold environments) and sexual selection (e.g., signaling sex, age, status). It is a universal characteristic of mammals, yet across species there is striking variation in the color, pattern, growth, and texture of hair. Moreover, many hair traits, such as tail stripes or thick woolly coats, seem to have evolved repeatedly in different mammal lineages. Hair also is a trait for which small genetic differences can have major phenotypic effects; for example, red hair in humans is due to variation at a single gene. This project applies cutting-edge genomic and comparative analyses to understand how genetic variation and selection have shaped this important anatomical feature (hair) in humans and other primates. In so doing, it also will provide a critical evolutionary context to understand one of the biological traits that make humans unique (relative hairlessness). Through conduct of the research, several undergraduate and graduate students, including individuals recruited from groups underrepresented in science, as well as a postdoctoral scholar, will receive extensive and broad scientific training. In addition, because many human and animal diseases are associated with hair changes and loss, this project is relevant for aspects of public health and dermatological and clinical research on hair/skin conditions. Animal hair also is an important commercial product; identifying the biological factors that shape hair characteristics in natural-living species could eventually improve the yield and quality of hair-based products. And finally, the project will generate a wealth of genetic and metric data on primate diversity that will contribute to research in conservation and evolutionary biology, as well as furthering research in biological anthropology.

该项目研究了核心生理和进化过程如何塑造生物学多样性。阐明遗传变化和选择压力如何导致性状变化是生物学的核心目标，而关键的是识别基因，形式和功能之间的联系，以及它们如何改变个人的适应性和物种的进化成功。此外，了解为什么在不同物种中独立进化的细胞和人体结构为何以及多少细胞结构可以解释进化如何采用多个途径来“解决”相同的问题。头发的生物学是研究遗传学，形式和功能之间这些联系的理想系统。头发是一种解剖特征，由自然选择（例如，提供针对捕食者的伪装，保护寄生虫，在寒冷环境中维持体温）和性选择（例如，信号性别，年龄，状态，状态）所塑造。它是哺乳动物的普遍特征，但是在整个物种上，头发的颜色，图案，生长和质地都有明显的变化。此外，许多发型特征，例如尾条或厚羊毛外套，似乎在不同的哺乳动物谱系中反复演变。头发也是一个特征，小遗传差异可以具有重大的表型作用。例如，人类中的红色头发是由于单个基因的变化。该项目应用了尖端的基因组和比较分析，以了解遗传变异和选择如何影响人类和其他灵长类动物中这种重要的解剖学特征（头发）。这样一来，它还将提供一个关键的进化环境，以了解使人类独特（相对无毛）的生物特征之一。通过这项研究，几位本科生和研究生，包括从科学领域人数不足的小组中招募的人以及博士后学者，将接受广泛而广泛的科学培训。此外，由于许多人类和动物疾病与头发变化和损失有关，因此该项目与公共卫生以及关于头发/皮肤状况的皮肤病学和临床研究有关。动物头发也是重要的商业产品；确定在天然生物物种中塑造头发特征的生物学因素最终可以提高基于头发产品的产量和质量。最后，该项目将产生大量有关灵长类动物多样性的遗传和度量数据，这将有助于保护和进化生物学的研究，并促进生物人类学的研究。