Dissection of Signaling Networks Maintaining Metabolic Homeostasis
维持代谢稳态的信号网络剖析
基本信息
- 批准号:1355097
- 负责人:
- 金额:$ 48.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-07-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The mechanisms of how organisms maintain metabolic homeostasis in light of significant environmental variation in food availability are not completely understood. Of particular interest of the field are the underlying mechanisms that form homeostatic responses to starvation. This research project will take advantage of the tractability of the model organism, Drosophila melanogaster and powerful molecular and imaging tools to address fundamental questions regarding metabolic decisions. One principal outcome of this proposal is to enhance understanding of the conservation of these metabolic networks. Preliminary results suggest that these networks are very likely to be highly conserved, and may therefore be leveraged for many practical applications, ranging from therapeutics to pest management. Preliminary data from the PI supports the hypothesis that the energy sensor, AMP-activated protein kinase (AMPK) regulates the secretion of Adipokinetic Hormone (AKH), which functions to mobilize energy stores and is required for behavioral and physiological responses to nutrient limitations. This project will investigate: i) Functional mechanisms of hormonal signaling on AKH cell physiology; ii) Connections between hormonal signaling systems and AMPK; and iii) Regulatory mechanisms of AKH cell excitability. The planned experiments in this proposal will contribute new information into the cellular signals within a defined cell population, which is required for generating specific behavioral and physiological changes to maintain energy homeostasis. This research project will also be used as a vehicle to extend undergraduate research opportunities to students, and also to faculty at regional institutions. These opportunities will provide research opportunities to underrepresented populations at both the faculty and student level. This seamless integration of research and education will have broad impacts, in providing the benefits of undergraduate research opportunities to a diversity of students.
生物如何在食物供应显著的环境变化下维持代谢稳态的机制尚不完全清楚。该领域特别感兴趣的是对饥饿形成稳态反应的潜在机制。该研究项目将利用模式生物——黑腹果蝇(Drosophila melanogaster)的可追踪性,以及强大的分子和成像工具来解决有关代谢决策的基本问题。该建议的一个主要结果是加强对这些代谢网络保护的理解。初步结果表明,这些网络很可能是高度保守的,因此可以用于许多实际应用,从治疗到害虫管理。来自PI的初步数据支持了能量传感器,amp活化蛋白激酶(AMPK)调节脂肪动力学激素(AKH)的分泌的假设,该激素的功能是调动能量储存,并且是对营养限制的行为和生理反应所必需的。本项目将研究:1)激素信号在AKH细胞生理中的作用机制;激素信号系统与AMPK之间的联系;iii) AKH细胞兴奋性的调控机制。本提案中计划的实验将为特定细胞群体中的细胞信号提供新的信息,这是产生特定行为和生理变化以维持能量稳态所必需的。这个研究项目也将被用来作为一个工具,扩大本科生的研究机会,也为区域机构的教师。这些机会将为教师和学生层面的代表性不足的人群提供研究机会。这种研究和教育的无缝整合将产生广泛的影响,为各种各样的学生提供本科研究机会的好处。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Erik Johnson其他文献
Musical Creativity in Autism: Exploring Growth through Collaborative Peer Interaction
自闭症的音乐创造力:通过同伴协作探索成长
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Erik Johnson;A. Lagasse - 通讯作者:
A. Lagasse
Understanding Light Harvesting in Radial Junction Amorphous Silicon Thin Film Solar Cellsbr /
了解径向结非晶硅薄膜太阳能电池中的光收集
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:4.6
- 作者:
Linwei Yu,;Soumyadeep Misra;Junzhuan Wang;Shengyi Qian;Martin Foldyna;Jun Xu;Yi Shi;Erik Johnson;Pere Roca i Cabarrocas - 通讯作者:
Pere Roca i Cabarrocas
The role of telencephalic NMDA receptors in avoidance learning in goldfish (Carassius auratus).
端脑 NMDA 受体在金鱼(鲫鱼)回避学习中的作用。
- DOI:
10.1037/0735-7044.117.3.548 - 发表时间:
2003 - 期刊:
- 影响因子:1.9
- 作者:
Xiaojuan Xu;Jennifer Bazner;Min Qi;Erik Johnson;Rob Freidhoff - 通讯作者:
Rob Freidhoff
Understanding Light Harvesting in Radial Junction Amorphous Silicon Thin Film Solar Cells<br />
- DOI:
- 发表时间:
2014 - 期刊:
- 影响因子:4.6
- 作者:
Linwei Yu,;Soumyadeep Misra;Junzhuan Wang;Shengyi Qian;Martin Foldyna;Jun Xu;Yi Shi;Erik Johnson;Pere Roca i Cabarrocas; - 通讯作者:
The Effect of Peer-Based Instruction on Rhythm Reading Achievement.
同伴教学对节奏阅读成绩的影响。
- DOI:
- 发表时间:
2011 - 期刊:
- 影响因子:0
- 作者:
Erik Johnson - 通讯作者:
Erik Johnson
Erik Johnson的其他文献
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{{ truncateString('Erik Johnson', 18)}}的其他基金
IRES Track II/Collaborative Research: PREEMPTIVE Multidisciplinary Natural Hazards Engineering Institute Series for Advanced Graduate Students
IRES Track II/合作研究:面向高级研究生的先发制人的多学科自然灾害工程学院系列
- 批准号:
1829085 - 财政年份:2018
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
CDS&E/Collaborative Research: A New Framework for Computational Model Validation
CDS
- 批准号:
1663667 - 财政年份:2017
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
Collaborative Research: Optimal Design of Smart Damping for Structural Systems to Mitigate the Impacts of Natural Hazards
合作研究:结构系统智能阻尼的优化设计,以减轻自然灾害的影响
- 批准号:
1436018 - 财政年份:2014
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
SAVI/Collaborative Research: Pacific Rim Earthquake Engineering Mitigation Protective Technologies International Virtual Environment
SAVI/合作研究:环太平洋地区地震工程减灾防护技术国际虚拟环境
- 批准号:
1446424 - 财政年份:2014
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
NEESR Planning/Collaborative Research: Toward Experimental Verification of Controllable Damping Strategies for Base Isolated Buildings
NEESR 规划/合作研究:基础隔离建筑可控阻尼策略的实验验证
- 批准号:
1344937 - 财政年份:2013
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
RAPID: NEES/E-Defense Collaboration for Design of E-Defense Smart Base Isolation Experiments
RAPID:NEES/E-Defense 合作设计 E-Defense 智能基地隔离实验
- 批准号:
1133023 - 财政年份:2011
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
A Database for the Sequencing of Environmental Movements
环境运动排序数据库
- 批准号:
0921942 - 财政年份:2009
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
The roles of the AMP-activated kinase in metabolic homeostasis in Drosophila
AMP 激活激酶在果蝇代谢稳态中的作用
- 批准号:
0920443 - 财政年份:2009
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
Controlled Substructure Identification for Structural Health Monitoring
用于结构健康监测的受控子结构识别
- 批准号:
0826634 - 财政年份:2008
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
NSF/Sandia: Discrepancy Sensitivity for Efficiently Choosing Computer Experiments in Design and Uncertainty Quantification
NSF/桑迪亚:在设计和不确定性量化中有效选择计算机实验的差异敏感性
- 批准号:
0331145 - 财政年份:2004
- 资助金额:
$ 48.6万 - 项目类别:
Standard Grant
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