CAREER: A novel nonlinear microscopy system and its application to characterization of biological media.

基于拉曼的微光谱学使用分子低频振动或旋转模式来识别和成像系统。尽管付出了巨大的努力，基于拉曼的微光谱学的应用仍然受到检测灵敏度有限的限制。该项目的主要目标是开发一种基于激光的仪器，能够检测和跟踪主要的生物细胞成分。该仪器设计将产生一种便携式和完全集成的激光仪器，该仪器经过优化，突破了现有的检测灵敏度限制，从而有利于广泛的研究人员使用。由此产生的装置将为拉曼表征技术在生物介质中的更广泛应用开辟道路。潜在的应用包括研究细胞分裂、分化或凋亡（死亡）等基本过程，这些过程伴随着细胞成分的重要空间重组。教育方案是基于有效的整合应用和基础研究，以培养本科生和研究生。该计划为研究生提供了几个独立而独特的项目，这些项目在技术和科学方面都具有挑战性，可以构成博士学位所需的原始科学研究的核心。该计划为理工科本科学生指定了子项目，这些学生对跨学科研究经验感兴趣，同时有机会与学术界和工业界的专业人士互动。该计划提供了与不同大学学院和部门密切合作的计划，这将影响物理系以外的研究工作，同时促进大学研究小组和中心之间的合作研究。对教学的其他贡献包括改进现有的研究生水平，固体光学性质，课程，开发新的研究生课程（量子电子学），并在现有的本科水平，高级物理实验室，课程中增加新的实验模块。外展活动包括参加全州范围的暑期本科生研究经验（SURE）计划，并为来自代表性不足和少数群体的高中生组织和举办暑期研究营。更多信息请访问http://physics.wvu.edu/people/feruz_ganikhanov

Raman-based microspectroscopy uses molecular low-frequency vibrational or rotational modes for the identification and imaging of systems. Despite intense efforts, the utility of Raman based microspectroscopy has been limited by limited detection sensitivity.The main objective of the project is to develop a laser-based instrument capable of detecting and tracking major biological cell constituents. The instrument design will yield a portable and fully integrated laser instrument that is optimized to break existing detection sensitivity limits, thereby favoring use by a broad range of researchers.The resulting device will open the way to wider applications of Raman based characterization techniques in biological media. Potential applications include the study of fundamental processes such as cell division, differentiation, or apoptosis (death), which are accompanied by a significant spatial reorganization of the cell constituents. The Education program is based on efficient integration of applied and fundamental research for the training of undergraduate and graduate students. The plan offers several separate and unique projects for graduate students, which are challenging in both technical and scientific aspects and can constitute a core for the original scientific research required for a PhD degree. The program specifies sub-projects for undergraduate students majoring in the fields of science and engineering who are interested in interdisciplinary research experiences while having the opportunity to interact with professionals within academia and industry. The program offers a plan of close collaboration with different university schools and departments which will impact the research efforts of those outside the Physics Department while facilitating collaborative research between the University's research groups and Centers. Other contribution to teaching include improvement to the existing graduate level, Optical Properties of Solids, course, development of a new graduate course (Quantum Electronics) and adding new laboratory modules to the existing undergraduate level, Advanced Physics Laboratory, course. Outreach activity includes participation in the statewide Summer Undergraduate Research Experience (SURE) program and organizing and hosting a summer research camp for high school students from underrepresented and minority groups.More information can be found at http://physics.wvu.edu/people/feruz_ganikhanov