IRES: U.S.-Netherlands Collaborative International Research Experience for Students in Mass Spectrometry and Ion Spectroscopy

IRES：美国-荷兰为质谱和离子光谱学学生提供的国际合作研究经验

• 批准号: 1357887
• 负责人: Mary Rodgers
• 金额: $ 25万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1357887&HistoricalAwards=false
• 关键词: IRES; U.S.; Netherlands; Collaborative; International

In this International Research Experience for Students (IRES) project, U.S. graduate and undergraduate students under the supervision of Professors Mary T. Rodgers of Wayne State University and Peter B. Armentrout of the University of Utah will participate in international collaborative research projects with Dutch counterpartners and institutions to investigate the roles of metal ion interactions in biology, energy and catalysis, and the environment. The biological, catalytic, and environmentally oriented mass spectrometry and spectroscopic studies they carry out are expected to add to the rapidly growing and evolving research areas that interest a broad community of researchers. Each U.S. cohort will be assigned collaborate on several projects, with each student acting as the lead researcher on a particular project. Outcomes from this IRES are expected to contribute to the underpinnings of these methodologies and add to their continuing development, while contributing to STEM workforce preparation.Twice a year for three years, U.S. student cohorts will travel to the Netherlands for month long research visits to participate in cooperative research projects that make use of unique Dutch instrumentation (laser systems and mass spectrometers) and cyber infrastructure at the Free Electron Lasers for Infrared eXperiments (FELIX) facility at the Radboud University Nijmegen. The FELIX facility in the Netherlands is an international user facility supported by an advanced technical staff as well as faculty, students, and postdoctoral fellows associated with the university. Planned experiments are designed to measure directly the infrared spectra of the metal-ligand complexes, thereby providing structural and mechanistic information through the analysis of the observed photodissociation pathways along with concomitant theoretical work. Because the FELIX facility welcomes a wide variety of researchers from around the globe, IRES participants should benefit from an exceptional, early career opportunity to interact with Dutch partners as well as researchers from other institutions and countries. Theoretical calculations, additional data analysis, and preparation of the results for presentation will continue after the students return to the U.S., culminating in the expected outcome of scientific publications, under the guidance of the U.S. PIs and Dutch mentors. Pre- and post visit surveys along with a three-year follow-up survey will be administered to assess the success of this IRES program. A website for this U.S.-Netherlands IRES program will make the results of the program available to participants, the broader scientific community, and the public.

在这个面向学生的国际研究体验(IRES)项目中，美国研究生和本科生将在韦恩州立大学的玛丽·T·罗杰斯教授和犹他大学的彼得·B·阿门特劳特教授的指导下，参与与荷兰合作伙伴和机构的国际合作研究项目，以研究金属离子相互作用在生物学、能源和催化以及环境中的作用。他们进行的生物、催化和面向环境的质谱学和光谱学研究预计将增加快速增长和发展的研究领域，引起广大研究人员的兴趣。每个美国学生将被分配到几个项目上进行合作，每个学生都是一个特定项目的首席研究员。预计IRES的成果将有助于这些方法的基础和持续发展，同时有助于STEM劳动力的准备。为期三年的美国学生队列将每年两次前往荷兰进行为期一个月的研究访问，参加合作研究项目，这些项目利用独特的荷兰仪器(激光系统和质谱仪)和拉德布德大学奈梅亨自由电子激光红外实验(FELIX)设施的网络基础设施。位于荷兰的Felix设施是一个国际用户设施，由高级技术人员以及与该大学相关的教职员工、学生和博士后研究员提供支持。计划中的实验旨在直接测量金属-配体络合物的红外光谱，从而通过分析观察到的光解离途径以及伴随的理论工作提供结构和机理信息。由于Felix机构欢迎来自全球各地的各种研究人员，IRES的参与者应该会受益于与荷兰合作伙伴以及来自其他机构和国家的研究人员进行互动的特殊的早期职业机会。在美国PIS和荷兰导师的指导下，学生返回美国后，将继续进行理论计算、额外的数据分析和结果展示准备，最终形成预期的科学出版物结果。将进行访问前和访问后的调查以及为期三年的跟踪调查，以评估IRES项目的成功。这个美国-荷兰IRES项目的网站将向参与者、更广泛的科学界和公众提供该项目的结果。

项目成果

Impact of the 2′- and 3′-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure

• DOI: 10.1007/s13361-019-02155-0
• 发表时间: 2019-03
• 期刊: Journal of The American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: L. Hamlow;Zachary J. Devereaux;H. Roy;N. A. Cunningham;G. Berden;J. Oomens;M. Rodgers

Structural and Energetic Effects of O2′-Ribose Methylation of Protonated Pyrimidine Nucleosides

质子化嘧啶核苷 O2α-核糖甲基化的结构和能量效应

• DOI: 10.1007/s13361-019-02300-9
• 发表时间: 2019
• 期刊: Journal of The American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: He, C. C.;Hamlow, L. A.;Zhu, Y.;Nei, Y.-w.;Fan, L.;McNary, C. P.;Maître, P.;Steinmetz, V.;Schindler, B.;Compagnon, I.
• 通讯作者: Compagnon, I.

Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines

• DOI: 10.1007/s13361-018-2047-2
• 发表时间: 2018-11-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Hamlow, L. A.;Zhu, Y.;Rodgers, M. T.
• 通讯作者: Rodgers, M. T.

Structures and Relative Glycosidic Bond Stabilities of Protonated 2′-Fluoro-Substituted Purine Nucleosides

• DOI: 10.1007/s13361-019-02222-6
• 发表时间: 2019-08-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Devereaux, Zachary J.;He, C. C.;Rodgers, M. T.
• 通讯作者: Rodgers, M. T.

Structural determination of arginine-linked cisplatin complexes via IRMPD action spectroscopy: arginine binds to platinum via NO − binding mode

通过 IMPD 作用光谱法测定精氨酸连接的顺铂复合物的结构：精氨酸通过 NO – 结合模式与铂结合

• DOI: 10.1039/d1cp03407c
• 发表时间: 2021
• 期刊: Physical Chemistry Chemical Physics
• 影响因子: 3.3
• 作者: He, C. C.;Hamlow, L. A.;Kimutai, B.;Roy, H. A.;Devereaux, Zachary J.;Cunningham, N. A.;Martens, J.;Berden, G.;Oomens, J.;Chow, C. S.
• 通讯作者: Chow, C. S.