MRI: Acquisition of a 9.4 T High Field Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for Biological and Materials Applications

MRI：购买用于生物和材料应用的 9.4 T 高场傅里叶变换离子回旋共振质谱仪

• 批准号: 0922819
• 负责人: Mary Rodgers
• 金额: $ 75.79万
• 依托单位: Wayne State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2012-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0922819&HistoricalAwards=false
• 关键词: MRI; Acquisition; 9.4; Field; Fourier

Faculty at the Department of Chemistry at Wayne State University (WSU) in Detroit, MI have been granted an award from Major Research Instrumentation (MRI) program to acquire a 9.4 T Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) to establish a biological mass spectrometry resource. The ultra high mass accuracy and resolving power, upper mass limit, and the dynamic range of this state-of-the-art instrumentation will provide support for transformative research and education in biology and the myriad interdisciplinary fields born of biology and chemistry, chemical engineering, environmental engineering, geology, and environmental health sciences. This instrument will provide a powerful tool for studies of a broad variety of topics in structural biology and the evolving fields of genomics, proteomics, glycomics, lipidomics, metabolomics, drug development, biological/nano materials and sensor applications, and methodology development for improved sensitivity and quantitation in mass analyses of biological molecules.This state-of-the-art FT-ICR MS will contribute to both research and educational infrastructure at WSU. It will be used as a central tool for numerous projects in a variety of Departments and several advanced laboratory courses at WSU, and will also provide benefits to the academic and industrial researchers that employ the WSU Central Instrumentation Facility (CIF) for mass spectral analyses. The instrument is expected to have a broad impact on education and training of undergraduate and graduate students, as well as the traditionally under-represented groups that make up ~33% of the WSU enrollment. The inherently interdisciplinary and collaborative nature of the projects that will benefit from this advanced instrumentation will promote WSUs training of scientists equipped to address the challenges facing the chemical, biological, geological, and engineering fields in the coming decades. Widespread dissemination of research outcomes will be achieved via presentations at scientific meetings, seminars at Universities, and research publications in a variety of scientific journals. Information regarding this FT-ICR MS instrument and research outcomes will also be disseminated to the general public and scientific communities via the Internet.

位于密歇根州底特律的韦恩州立大学（WSU）化学系获得了主要研究仪器（MRI）项目的奖励，获得9.4 T傅立叶变换离子回旋共振质谱仪（FT-ICR MS），以建立生物质谱仪资源。这种先进仪器的超高质量精度和分辨率、质量上限和动态范围，将为生物学以及生物与化学、化学工程、环境工程、地质学和环境健康科学等众多跨学科领域的变革性研究和教育提供支持。该仪器将为结构生物学和基因组学、蛋白质组学、糖组学、脂质组学、代谢组学、药物开发、生物/纳米材料和传感器应用、以及提高生物分子质量分析灵敏度和定量的方法开发等领域的广泛主题研究提供强大的工具。这台最先进的FT-ICR MS将为华盛顿州立大学的研究和教育基础设施做出贡献。它将被用作WSU多个部门的众多项目和几个高级实验室课程的中心工具，也将为使用WSU中央仪器设备（CIF）进行质谱分析的学术和工业研究人员提供好处。该工具预计将对本科生和研究生的教育和培训产生广泛的影响，以及传统上代表性不足的群体，占WSU入学人数的33%左右。这些项目的跨学科和协作性质将受益于这些先进的仪器，这将促进WSUs培养科学家，使他们能够应对未来几十年化学、生物、地质和工程领域面临的挑战。研究成果的广泛传播将通过在科学会议、大学研讨会和在各种科学期刊上发表研究论文来实现。有关FT-ICR质谱仪和研究成果的信息也将通过互联网向公众和科学界传播。

项目成果

Impact of the 2′- and 3′-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure

• DOI: 10.1007/s13361-019-02155-0
• 发表时间: 2019-03
• 期刊: Journal of The American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: L. Hamlow;Zachary J. Devereaux;H. Roy;N. A. Cunningham;G. Berden;J. Oomens;M. Rodgers

Experimental and Computational Study of the Group 1 Metal Cation Chelates with Lysine: Bond Dissociation Energies, Structures, and Structural Trends

• DOI: 10.1021/acs.jpcb.8b11967
• 发表时间: 2019-03-07
• 期刊: JOURNAL OF PHYSICAL CHEMISTRY B
• 影响因子: 3.3
• 作者: Clark, Amy A.;Yang, Bo;Armentrout, P. B.
• 通讯作者: Armentrout, P. B.

Protonated Asparaginyl-Alanine Decomposition: a TCID, SORI-CID, and Computational Analysis

质子化天冬酰胺酰丙氨酸分解：TCID、SORI-CID 和计算分析

• DOI: 10.1007/s13361-018-2052-5
• 发表时间: 2018
• 期刊: Journal of The American Society for Mass Spectrometry
• 影响因子: 3.2
• 作者: Boles, Georgia C.;Wu, R. R.;Rodgers, M. T.;Armentrout, P. B.
• 通讯作者: Armentrout, P. B.

Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines

• DOI: 10.1007/s13361-018-2047-2
• 发表时间: 2018-11-01
• 期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
• 影响因子: 3.2
• 作者: Hamlow, L. A.;Zhu, Y.;Rodgers, M. T.
• 通讯作者: Rodgers, M. T.

Relative glycosidic bond stabilities of naturally occurring methylguanosines: 7-methylation is intrinsically activating

天然存在的甲基鸟苷的相对糖苷键稳定性：7-甲基化具有内在激活作用

• DOI: 10.1177/1469066718798097
• 发表时间: 2018
• 期刊: European Journal of Mass Spectrometry
• 影响因子: 1.3
• 作者: Devereaux, Zachary J;Zhu, Y;Rodgers, MT
• 通讯作者: Rodgers, MT