MRI: Acquisition of a 9.4 T High Field Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for Biological and Materials Applications

密歇根州底特律市韦恩州立大学（WSU）化学系的教师获得了重大研究仪器（MRI）计划的奖励，以获得9.4 T傅里叶变换离子回旋共振质谱仪（FT-ICR MS），以建立生物质谱资源。超高的质量精度和分辨能力，质量上限和这种最先进的仪器的动态范围将为生物学的变革性研究和教育以及生物学和化学，化学工程，环境工程，地质学和环境健康科学所产生的无数跨学科领域提供支持。 该仪器将为结构生物学和基因组学、蛋白质组学、糖组学、脂质组学、代谢组学、药物开发、生物/纳米材料和传感器应用等不断发展的领域的各种主题的研究提供强大的工具，和方法的发展，以提高灵敏度和定量的生物分子的质量分析。这一国家的最先进的FT-ICR MS将有助于WSU的研究和教育基础设施。 它将被用来作为一个中央工具，在各种部门和几个先进的实验室课程在WSU的众多项目，也将提供利益的学术和工业研究人员采用WSU中央仪器设备（CIF）的质谱分析。 该工具预计将对本科生和研究生的教育和培训产生广泛的影响，以及传统上代表性不足的群体，占WSU入学人数的33%。 将受益于这种先进仪器的项目的固有的跨学科和协作性质将促进WSU培训科学家，以应对未来几十年化学，生物，地质和工程领域面临的挑战。 研究成果将通过在科学会议、大学研讨会上的演讲以及在各种科学期刊上发表研究论文来广泛传播。 有关FT-ICR MS仪器和研究成果的信息也将通过互联网向公众和科学界传播。

Faculty at the Department of Chemistry at Wayne State University (WSU) in Detroit, MI have been granted an award from Major Research Instrumentation (MRI) program to acquire a 9.4 T Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) to establish a biological mass spectrometry resource. The ultra high mass accuracy and resolving power, upper mass limit, and the dynamic range of this state-of-the-art instrumentation will provide support for transformative research and education in biology and the myriad interdisciplinary fields born of biology and chemistry, chemical engineering, environmental engineering, geology, and environmental health sciences. This instrument will provide a powerful tool for studies of a broad variety of topics in structural biology and the evolving fields of genomics, proteomics, glycomics, lipidomics, metabolomics, drug development, biological/nano materials and sensor applications, and methodology development for improved sensitivity and quantitation in mass analyses of biological molecules.This state-of-the-art FT-ICR MS will contribute to both research and educational infrastructure at WSU. It will be used as a central tool for numerous projects in a variety of Departments and several advanced laboratory courses at WSU, and will also provide benefits to the academic and industrial researchers that employ the WSU Central Instrumentation Facility (CIF) for mass spectral analyses. The instrument is expected to have a broad impact on education and training of undergraduate and graduate students, as well as the traditionally under-represented groups that make up ~33% of the WSU enrollment. The inherently interdisciplinary and collaborative nature of the projects that will benefit from this advanced instrumentation will promote WSUs training of scientists equipped to address the challenges facing the chemical, biological, geological, and engineering fields in the coming decades. Widespread dissemination of research outcomes will be achieved via presentations at scientific meetings, seminars at Universities, and research publications in a variety of scientific journals. Information regarding this FT-ICR MS instrument and research outcomes will also be disseminated to the general public and scientific communities via the Internet.