Thermochemistry of Noncovalent Metal-Ligands Bonds of Biological Relevance

韦恩州立大学的Mary Rodgers在实验物理化学项目的支持下进行研究，旨在获得关于金属离子和配体之间非共价相互作用的绝对定量的热化学、动力学和结构信息。选择用于研究的系统要么具有生物学相关性，要么具有分析实用性，包括：模型芳香配体、MALDI基质、核酸碱基、模型磷酸酯、与碱、碱土和过渡金属离子相互作用的单核苷酸和二核苷酸。这些实验旨在直接测量金属-配体相互作用的绝对强度，或金属-配体配合物活化解离过程的活化能。这些研究还以伴随的理论工作和分解途径分析的形式提供了有关这种键激活过程的结构和机制信息。结果有望提供准确的热力学信息对各种金属配体配合物；这些信息正在被编入热化学数据库，这将使表征和理解周期性质和趋势成为可能。生物质谱法是一项快速发展和发展的技术，已经引起了广泛的研究人员的兴趣。这项研究的结果将有助于该方法的基础，并增加其持续发展。

Mary Rodgers of Wayne State University is supported by the Experimental Physical Chemistry Program to carry out research designed to obtain absolute quantitative thermochemical, dynamical, and structural information regarding noncovalent interactions between metal ions and ligands. The systems chosen for study are of either biological relevance or analytical utility and include: model aromatic ligands, MALDI matrices, nucleic acid bases, model phosphate esters, and mono- and dinucleotides interacting with alkali, alkaline-earth, and transition metal ions. The experiments are designed to measure directly either the absolute strength of the metal-ligand interaction, or the activation energy for activated dissociation processes of the metal-ligand complexes. These studies also provide structural and mechanistic information regarding such bond activation processes obtained in the form of concomitant theoretical work and through the analysis of decomposition pathways. Outcomes are expected to provide accurate thermodynamic information on a wide variety of metal-ligand complexes; this information is being compiled into thermochemical databases that will enable the characterization and understanding of periodic properties and trends.Biological mass spectrometry is a rapidly growing and evolving technology that has captured the interest of a broad community of researchers. Outcomes from this research will contribute to the underpinnings of the methodology, and add to its continuing development.