IRES: Application of Biochemistry and Analytical Chemistry for Real-World Tasks in Ppublic Health and Biomedicine

IRES：生物化学和分析化学在公共卫生和生物医学现实世界任务中的应用

• 批准号: 1358222
• 负责人: Moon-Soo Kim
• 金额: $ 25万
• 依托单位: Western Kentucky University Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2018-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1358222&HistoricalAwards=false
• 关键词: IRES; Application; Biochemistry; Analytical; Chemistry

This IRES award will provide research experiences to undergraduate students from Western Kentucky University (WKU) in South Korea at Pusan National University and Changwon National University. The WKU students will work on projects in biochemistry and analytical chemistry with the PI or Co-PI and respective South Korean collaborators. The PI, Professor Moon-Soo Kim from WKU, and Professor Haesik Yang from Pusan National University will collaborate on the use of sequence-specific Zinc Finger Proteins (ZFPs) and Transcriptional Activator-Like Effectors (TALEs) for the detection of pathogens. They seek improvements in detection sensitivity for this technique by using electrochemical detection with redox cycling. The development of a point-of-care diagnostic for pathogen detection is expected from this project. The Co-Pi, Professor Eric Conte from WKU, and Professor Yong-Ill Lee from Changwon National University will collaborate on the use of Magnetic Zirconia particles for the separation of chiral racemic drug mixtures. The separation of chiral racemic mixtures is a challenge in biomedicine where typically only one enantiomer will have biological activity. Magnetic zirconia particles show promise for separating a number of important racemic mixtures and subsequent isolation of the biologically important chiral molecule. Separating and isolating the pharmaceutically active chiral substance is important for studying a drug?s metabolic route.A strengthened joint collaboration, involving WKU undergraduate students, will result between the WKU investigators from a predominately undergraduate institution and Korean collaborators at two internationally recognized Ph.D. granting institutions (Pusan and Changwon National Universities). In addition, this experience is designed to expose students to education within a different cultural milieu. They will gain an appreciation for higher education in a country other than their own and gain research experience in an international environment. Also, a greater cultural appreciation will result. WKU students will work in the laboratory of the PI or Co-PI during the academic year and visit their host Korean University during the summertime. Qualified underrepresented students from WKU will be given priority for this overseas visit, including students from nearby Appalachian counties. These students will be least likely to have the means to visit a foreign land and in general lack exposure to diverse cultures.

该 IRES 奖项将为韩国西肯塔基大学 (WKU) 釜山国立大学和昌原国立大学的本科生提供研究经验。温州肯恩大学的学生将与 PI 或 Co-PI 以及各自的韩国合作者一起开展生物化学和分析化学项目。首席研究员、温州肯恩大学的 Moon-Soo Kim 教授和釜山国立大学的 Haesik Yang 教授将合作使用序列特异性锌指蛋白 (ZFP) 和转录激活因子样效应器 (TALE) 来检测病原体。他们通过使用电化学检测和氧化还原循环来寻求提高该技术的检测灵敏度。该项目预计将开发出用于病原体检测的即时诊断方法。 Co-Pi、WKU 的 Eric Conte 教授和昌原国立大学的 Yong-Ill Lee 教授将合作研究使用磁性氧化锆颗粒来分离手性外消旋药物混合物。手性外消旋混合物的分离是生物医学中的一个挑战，通常只有一种对映体具有生物活性。磁性氧化锆颗粒有望分离许多重要的外消旋混合物，并随后分离生物学上重要的手性分子。分离和隔离具有药物活性的手性物质对于研究药物的代谢途径非常重要。来自温州肯恩大学本科生的温州肯恩大学研究人员和两个国际公认的博士生的韩国合作者将加强联合合作。授予机构（国立釜山大学和昌原大学）。此外，这种体验旨在让学生接受不同文化环境中的教育。 他们将对异国的高等教育产生欣赏，并在国际环境中获得研究经验。此外，还将带来更大的文化欣赏。 温州肯恩大学的学生将在学年期间在 PI 或 Co-PI 的实验室工作，并在暑假期间访问所在的韩国大学。此次海外访问将优先考虑温州肯恩大学合格的代表性不足的学生，包括来自附近阿巴拉契亚县的学生。这些学生最不可能有能力去异国他乡，并且通常缺乏接触不同文化的机会。