IRES: Application of Biochemistry and Analytical Chemistry for Real-World Tasks in Ppublic Health and Biomedicine

这项IRES奖学金将为来自韩国西肯塔基大学（WKU）、釜山国立大学和昌原国立大学的本科生提供研究经验。WKU学生将与PI或Co-PI以及各自的韩国合作者一起研究生物化学和分析化学项目。PI、WKU的Moon-Soo Kim教授和釜山国立大学的Haesik Yang教授将合作使用序列特异性锌指蛋白（ZFPs）和转录激活物样效应物（TALEs）来检测病原体。他们寻求通过使用氧化还原循环的电化学检测来提高该技术的检测灵敏度。预计该项目将开发一种即时诊断的病原体检测方法。WKU的Eric Conte教授和昌原国立大学的Yong-Ill Lee教授将合作使用磁性氧化锆颗粒分离手性外消旋药物混合物。手性外消旋混合物的分离是生物医学中的一个挑战，通常只有一种对映体具有生物活性。磁性氧化锆颗粒显示出分离一些重要的外消旋混合物和随后分离生物学上重要的手性分子的希望。分离和分离具有药用活性的手性物质对药物的研究很重要。S代谢途径。WKU的研究人员来自一个以本科生为主的机构，他们将与两个国际公认的博士学位授予机构（釜山国立大学和昌原国立大学）的韩国合作者加强联合合作，包括WKU的本科生。此外，这种体验旨在让学生在不同的文化环境中接受教育。他们将获得对本国以外国家高等教育的欣赏，并在国际环境中获得研究经验。同时，文化鉴赏力也会提高。WKU学生将在学年期间在PI或Co-PI的实验室工作，并在夏季访问他们的东道主韩国大学。本次海外访问将优先考虑来自西堪萨斯大学的合格学生，包括来自附近阿巴拉契亚县的学生。这些学生最不可能有机会去国外旅游，而且通常缺乏接触不同文化的机会。

This IRES award will provide research experiences to undergraduate students from Western Kentucky University (WKU) in South Korea at Pusan National University and Changwon National University. The WKU students will work on projects in biochemistry and analytical chemistry with the PI or Co-PI and respective South Korean collaborators. The PI, Professor Moon-Soo Kim from WKU, and Professor Haesik Yang from Pusan National University will collaborate on the use of sequence-specific Zinc Finger Proteins (ZFPs) and Transcriptional Activator-Like Effectors (TALEs) for the detection of pathogens. They seek improvements in detection sensitivity for this technique by using electrochemical detection with redox cycling. The development of a point-of-care diagnostic for pathogen detection is expected from this project. The Co-Pi, Professor Eric Conte from WKU, and Professor Yong-Ill Lee from Changwon National University will collaborate on the use of Magnetic Zirconia particles for the separation of chiral racemic drug mixtures. The separation of chiral racemic mixtures is a challenge in biomedicine where typically only one enantiomer will have biological activity. Magnetic zirconia particles show promise for separating a number of important racemic mixtures and subsequent isolation of the biologically important chiral molecule. Separating and isolating the pharmaceutically active chiral substance is important for studying a drug?s metabolic route.A strengthened joint collaboration, involving WKU undergraduate students, will result between the WKU investigators from a predominately undergraduate institution and Korean collaborators at two internationally recognized Ph.D. granting institutions (Pusan and Changwon National Universities). In addition, this experience is designed to expose students to education within a different cultural milieu. They will gain an appreciation for higher education in a country other than their own and gain research experience in an international environment. Also, a greater cultural appreciation will result. WKU students will work in the laboratory of the PI or Co-PI during the academic year and visit their host Korean University during the summertime. Qualified underrepresented students from WKU will be given priority for this overseas visit, including students from nearby Appalachian counties. These students will be least likely to have the means to visit a foreign land and in general lack exposure to diverse cultures.