1,2,3-Triazoles as Crucial Ligands in Metal Catalysis

1,2,3-三唑作为金属催化中的关键配体

• 批准号: 1362057
• 负责人: Xiaodong Shi
• 金额: $ 37.5万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362057&HistoricalAwards=false
• 关键词: Triazoles; Crucial; Ligands; Metal; Catalysis

The understanding of basic ligand-metal interactions translates to the development of new catalysts to promote important and challenging chemical transformations using relatively simple precursors. Although the 1,2,3-triazole ring system was introduced to the chemical community via "click-chemistry," with numerous applications applied to chemical, biological and materials research, most of the reported efforts focused on the application of this efficient linking strategy to bring functional groups in close proximity. In contrast, little is known about the fundamental reactivity of TAs upon interaction with catalytic metals. This grant will develop an extensive set of catalysts based upon such interaction. This project is also integrated into an outreach program to introduce undergraduate students from the state of West Virginia to advanced organic synthesis and catalysis.Through this award, funded by the Chemical Synthesis Program (SYN) of the Division of Chemistry, Prof. X. Shi from the West Virginia University investigates the coordination ability of 1,2,3-triazoles (TAs) toward transition metal cations. With the ability to prepare various TA-derivatives, Prof. Shi's lab has studied TA-coordination with various transition metal cations over the last five years, with novel TA complexes obtained with excellent stability and striking reactivity. These discoveries have challenged the assumption that TAs are poor ligands. In this project, new TA-complexes are being synthesized and investigated, both for fundamental reasons and for industrial applications (new catalyst design). These systems include triazole-Au-catalyzed alkyne activation and triazole-directed C-H activation.

对基本配体-金属相互作用的理解转化为新催化剂的开发，以使用相对简单的前体促进重要且具有挑战性的化学转化。 虽然1，2，3-三唑环系统是通过“点击化学”引入化学界的，并在化学、生物和材料研究中有许多应用，但大多数报道的努力都集中在这种有效连接策略的应用上，以使官能团非常接近。 与此相反，很少有人知道的基本反应性的TA与催化金属的相互作用。 这笔赠款将在这种相互作用的基础上开发一套广泛的催化剂。 该项目也被纳入一个推广计划，介绍来自西弗吉尼亚州的本科生先进的有机合成和催化。通过这个奖项，由化学系的化学合成计划（SYN）资助，教授X。来自西弗吉尼亚大学的Shi研究了1，2，3-三唑（TA）对过渡金属阳离子的配位能力。 凭借制备各种TA衍生物的能力，Shi教授的实验室在过去五年中研究了TA与各种过渡金属阳离子的配位，获得了具有优异稳定性和显着反应性的新型TA配合物。 这些发现挑战了TA是不良配体的假设。 在这个项目中，新的TA配合物正在合成和研究，无论是基本原因和工业应用（新的催化剂设计）。 这些系统包括三唑-Au催化的炔活化和三唑导向的C-H活化。