CAREER: Developing 1,2,3-triazole skeletons as novel chiral building blocks in asymmetric catalysis

职业：开发 1,2,3-三唑骨架作为不对称催化中的新型手性结构单元

• 批准号: 0844602
• 负责人: Xiaodong Shi
• 金额: $ 55万
• 依托单位: West Virginia University Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0844602&HistoricalAwards=false
• 关键词: CAREER; Developing; triazole; skeletons; novel

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This project will work on the development of 1,2,3-triazole and its derivatives as novel ligands in promoting stereoselective functional group transformation for facile C-C and C-N bonds construction. While formation of 1,2,3-triazole through click-chemistry has been extensively applied in chemical and biological researches, most of the reported research focused on the application of click chemistry as biological compatible linkers and little progress has been made in the development of this interesting structural motif as new functional group in asymmetric catalysis. Studies to further elucidate the unique functionality of this motif and how it influences the metal catalyst reactivity will be undertaken. Combinatorial type screening of ligands with various transition metal cations will be carried out to identify new useful catalysts. Hypothesis driven studies of new asymmetric catalysis will be also performed. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Xiaodong Shi of the Department of Chemistry at West Virginia University. Professor Shi's research efforts revolve around the development of new methods for the preparation of 1,2,3-triazole derivatives and asymmetric catalysis. Such chemistry will contribute to the fundamental understanding of ligand influence on catalyst reactivity and stereoselectivity. Successful development of the methodology will have an impact on synthesis in the pharmaceutical and chemical industries.

该奖项是根据2009年美国复苏和再投资法案（公法111-5）资助的。本计画将开发1，2，3-三氮唑及其衍生物作为新型配体，以促进立体选择性的官能团转化，使C-C键及C-N键易于建构。 通过点击化学形成1，2，3-三唑已广泛应用于化学和生物学研究，但大多数报道的研究集中在点击化学作为生物相容性连接体的应用上，而在开发这种有趣的结构基序作为新的不对称催化功能基团方面进展甚微。 研究，以进一步阐明这一主题的独特功能，以及它如何影响金属催化剂的反应性将进行。 将进行具有各种过渡金属阳离子的配体的组合类型筛选以鉴定新的有用催化剂。 新的不对称催化的假设驱动的研究也将进行。 有了这个奖项，有机和高分子化学计划正在支持西弗吉尼亚大学化学系的Xiaodong Shi教授的研究。 石教授的研究工作围绕着1，2，3-三唑衍生物的制备和不对称催化的新方法的开发。 这种化学反应将有助于从根本上了解配体对催化剂反应性和立体选择性的影响。 该方法的成功开发将对制药和化学工业的合成产生影响。