Reactivity and Selectivity in Radical Polar Crossover Reactions

在这个由化学系化学合成项目资助的项目中，Gregory K.爱荷华州大学的Friestad正在建立一系列新的碳-碳键构建反应，用于合成生物活性化合物。 这项工作涉及通过自由基和极性反应进行的反应的基本反应性研究，所谓的“自由基-极性交叉反应”，以及它们在制备复杂含氮化合物中的应用。 这项工作的一个更广泛的影响是自由基反应在许多化学分支学科中的应用。 可以通过新反应制备的化合物类型对健康科学研究产生了更广泛的影响，特别是在药物发现方面，从而改善了社会中个人的福祉。 将自由基和离子转化结合到一个操作中可以节省时间、能源和材料，对化学合成的可持续性产生更广泛的影响。 该项目还开发了更加多样化的人力资源，这有助于依赖科技教育和培训的工业的经济增长，该项目扩大了对亚氨基化合物进行立体选择性自由基加成的多功能性，以便杂环基团可以存在于前体中，产生带有手性胺和杂环化合物的结构。 这些进展正在用于合成药物化学中重要的生物活性化合物。 其他研究正在开发反应，其中含氧或含氮杂环结构单元在新的反应过程中形成，在单一操作中使用自由基和离子键结构的组合。 弗里斯塔德教授还在开发方法，以增加大学与邻近社区之间的联系，这些社区拥有大量少数民族人口，传统上在物理科学中代表性不足，目标是在更多样化背景的人中建立科学兴趣和经验。

In this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Gregory K. Friestad of the University of Iowa is establishing a series of new carbon-carbon bond construction reactions for synthesizing biologically active compounds. This effort involves fundamental reactivity studies in reactions which proceed via both radical and polar reactions, so-called "radical-polar crossover reactions," and their application to prepare complex nitrogen-containing compounds. A broader impact of this work is the application of free radical reactions to many subdisciplines of chemistry. The types of compounds that can be prepared through the new reactions have broader impacts on health sciences research, particularly in drug discovery, thereby improving the well-being of individuals in society. Combining radical and ionic transformations into one operation saves time, energy, and materials, with broader impact upon sustainability of chemical synthesis. The project is also developing more diverse personnel resources, which assists in the economic growth of industries dependent upon science and technology education and training.This project is expanding the versatility of stereoselective radical additions to imino compounds, so that heterocyclic groups may be present in the precursors, producing structures bearing chiral amines in combination with heterocycles. These developments are being used in synthesis of biologically active compounds of importance in medicinal chemistry. Additional studies are developing reactions in which the oxygen- or nitrogen-containing heterocyclic structural units are formed during the new reactions, using combinations of radical and ionic bond constructions in a single operation. Professor Friestad is also developing approaches to increase outreach between the university and neighboring communities with significant populations of minorities, which are traditionally underrepresented in physical sciences with the goal of building science interests and experiences among people of more diverse backgrounds.