Asymmetric Radical Addition Reactions

通过这一奖项，有机和高分子化学项目支持爱荷华大学化学系格雷戈里·K·弗里斯塔德教授的研究。该项目的重点是开发新的立体选择性方法，通过自由基加成反应实现不对称胺的合成。特别是，这些研究将扩大锰介导的自由基加成反应的范围和效率，为构建四元碳立体中心提供新的方法，并研究自由基加成对C=N键的不对称催化作用。我们将研究一种新的手性胺的自由基加成方法，包括在手性烯胺的C=C键上加成，然后通过串联键结构进行立体选择性捕获。这个项目将有助于了解产生手性胺的自由基加成反应的化学知识。由于手性胺在药物化学中扮演着重要的角色，这些研究有望对健康科学的研究产生广泛的影响。该项目还将提供重要的本科生、研究生和博士后培训，为从事健康科学研究工作做准备。

With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Gregory K. Friestad of the Chemistry Department at the University of Iowa. The project focuses on the development of new stereoselective methods to achieve asymmetric amine synthesis via free radical addition reactions. In particular, these studies will expand the scope and improve the efficiency of Mn-mediated radical additions, provide new methods for the construction of quaternary carbon stereocenters, and investigate asymmetric catalysis of radical additions to C=N bonds. A new radical addition approach to chiral amines, involving addition to the C=C bond of chiral enamides with subsequent stereoselective trapping by tandem bond constructions, will be studied. This project will contribute to knowledge of the chemistry of radical addition reactions that generate chiral amines. Since chiral amines play crucial roles in pharmaceutical chemistry, these investigations are expected to have broad impact on research in the health sciences. This project will also provide important undergraduate, graduate and postdoctoral training in preparation for careers in health sciences research.