Asymmetric Radical Addition Reactions

不对称自由基加成反应

• 批准号: 0749850
• 负责人: Gregory Friestad
• 金额: $ 39万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0749850&HistoricalAwards=false
• 关键词: Asymmetric; Radical; Addition; Reactions

With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Gregory K. Friestad of the Chemistry Department at the University of Iowa. The project focuses on the development of new stereoselective methods to achieve asymmetric amine synthesis via free radical addition reactions. In particular, these studies will expand the scope and improve the efficiency of Mn-mediated radical additions, provide new methods for the construction of quaternary carbon stereocenters, and investigate asymmetric catalysis of radical additions to C=N bonds. A new radical addition approach to chiral amines, involving addition to the C=C bond of chiral enamides with subsequent stereoselective trapping by tandem bond constructions, will be studied. This project will contribute to knowledge of the chemistry of radical addition reactions that generate chiral amines. Since chiral amines play crucial roles in pharmaceutical chemistry, these investigations are expected to have broad impact on research in the health sciences. This project will also provide important undergraduate, graduate and postdoctoral training in preparation for careers in health sciences research.

通过这个奖项，有机和大分子化学项目支持了爱荷华大学化学系的Gregory K. Friestad教授的研究。该项目侧重于开发新的立体选择方法，通过自由基加成反应实现不对称胺合成。特别是，这些研究将扩大mn介导自由基加成的范围和提高效率，为构建季碳立体中心提供新的方法，并研究自由基加成对C=N键的不对称催化作用。本文将研究一种新的手性胺自由基加成方法，即手性酰胺的C=C键加成，并通过串联键结构进行立体选择性捕获。这个项目将有助于了解产生手性胺的自由基加成反应的化学性质。由于手性胺在药物化学中起着至关重要的作用，这些研究有望对健康科学的研究产生广泛的影响。该项目还将提供重要的本科生、研究生和博士后培训，为从事健康科学研究做好准备。