Towards Unraveling Photoprotection in Skin Chromophores

揭开皮肤发色团的光保护作用

• 批准号: 1362237
• 负责人: Susanne Ullrich
• 金额: $ 44.1万
• 依托单位: University of Georgia Research Foundation Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362237&HistoricalAwards=false
• 关键词: Towards; Unraveling; Photoprotection; Skin; Chromophores

In this award, funded by the Chemical Structure, Dynamics and Mechanisms (CSDM-A) Program of the Division of Chemistry, Professor Susanne Ullrich of the University of Georgia and her graduate student researchers are working to develop a better understanding of the photochemical processes underlying the protective properties of the molecular building blocks that make up eumelanin (the skin pigment in humans). Prof. Ullrich and her students will be collaborating on this project with the groups of Prof. Vasilios Stavros of the University of Warwick and Prof. Martin J. Paterson of Heriot-Watt University, both in the United Kingdom. Graduate students working on this project at the University of Georgia will receive excellent training in experimental and theoretical chemistry and will have the added benefit of working with some distinguished international scientists. Prof. Ullrich will also work on an educational project with Mr. Nick Barker, a Teaching Fellow in the Department of Chemistry at the University of Warwick, working with the Society of Physics Students at University of Georgia to develop a physics roadshow.Prof. Ullrich and her research group are conducting a series of experiments to study the photochemistry of the building blocks that make up the light-absorbing part of the skin pigment eumelanin, including 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole carboxylic acid (DHICA). Among the experiments to be carried out are: (1) the gas phase time-resolved photoelectron spectroscopy of DHI and DHICA; (2) the gas phase time-resolved ion yield spectroscopy of both species; (3) the gas-phase time-resolved total kinetic energy release spectroscopy of the species; (4) the condensed phase transient ultraviolet absorption spectroscopy measurements of DHI and DHICA and (5) the transient infrared absorption spectroscopy measurements of both species in the condensed phase. Students working on this project will receive excellent training in chemical physics that will prepare them to become globally-engaged members of the technical workforce.

在这个奖项，由化学系的化学结构，动力学和机制（CSDM-A）计划资助，格鲁吉亚大学的Susanne Ullrich教授和她的研究生研究人员正在努力更好地了解构成真黑素（人类皮肤色素）的分子构建块的保护特性的光化学过程。 Ullrich教授和她的学生将与联合王国的沃里克大学的Vasilios Stavros教授和Heriot-Watt大学的Martin J. Paterson教授合作开展这一项目。 在格鲁吉亚大学从事这一项目的研究生将接受实验和理论化学方面的优秀培训，并将与一些杰出的国际科学家合作。 Ullrich教授还将与沃里克大学化学系的教学研究员Nick Barker先生合作开展一个教育项目，与格鲁吉亚大学物理学生协会合作，开展物理路演。Ullrich教授和她的研究小组正在进行一系列实验，研究构成光的基本成分的光化学-吸收部分皮肤色素的真黑素，包括5，6-二羟基吲哚（DHI）和5，6-二羟基吲哚羧酸（DHICA）。 实验包括：（1）DHI和DHICA的气相时间分辨光电子能谱，（2）两种物种的气相时间分辨离子产额谱，（3）物种的气相时间分辨总动能释放谱，（4）物种的气相时间分辨总动能释放谱，（5）物种的气相时间分辨总动能释放谱，（6）物种的气相时间分辨总动能释放谱，（7）物种的气相时间分辨总动能释放谱，（8）物种的气相时间分辨总动能释放谱。（4）DHI和DHICA的凝聚相瞬态紫外吸收光谱测量和（5）瞬态红外吸收光谱测量的两个物种在凝聚相。 从事该项目的学生将接受化学物理方面的优秀培训，使他们成为全球技术劳动力的一员。

项目成果

Ultrafast transient absorption spectroscopy of the photodecarbonylation of photo-oxadibenzocyclooctyne (photo-ODIBO)

光-氧杂二苯并环辛炔 (photo-ODIBO) 光脱羰的超快瞬态吸收光谱

• DOI: 10.1063/5.0041161
• 发表时间: 2021
• 期刊: The Journal of Chemical Physics
• 作者: Shenje, Learnmore;Thompson, William;Ren, Zichun;Lin, Nannan;Popik, Vladimir;Ullrich, Susanne
• 通讯作者: Ullrich, Susanne