RUI: Cyclometalated Platinum Complexes Having Selective Reactivity and Applications in Catalytic, Photophysical, and Bio-Organometallic Systems

RUI：具有选择性反应活性的环金属化铂配合物及其在催化、光物理和生物有机金属系统中的应用

• 批准号: 1362858
• 负责人: Craig Anderson
• 金额: $ 21.6万
• 依托单位: Bard College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1362858&HistoricalAwards=false
• 关键词: RUI; Cyclometalated; Platinum; Complexes; Having

In this project funded by the Chemical Structure, Dynamics and Mechanisms B Program of the Chemistry Division, Professor Craig M. Anderson of the Chemistry Department at Bard College will investigate the synthesis of transition cyclometalated complexes. The study of these complexes may advance the understanding of fundamental catalytic reactions and eventually contribute in areas with energy implications, as cyclometalated complexes are well known in the study of artificial photosynthetic devices. Another very important aspect of this work is that it will involve undergraduates at all levels from first-year to senior students. It will also allow students to gain experience in many diverse skills and techniques such as synthesis, characterization, and analysis of results. The students will become well trained in order to continue further scientific studies, disseminate their work through written publications and oral presentations, and develop new hypotheses for testing.Cyclometalated transition metal complexes are a very versatile group of compounds whose varied applications include acting as catalysts, sensors, artificial photosynthetic devices, and bio-organometallic agents. The effect that ligand architecture exerts on selectivity and reactivity of cyclometalated complexes is important to understand, as the coordination environment determines both reaction functionality and efficacy. First, the physical and chemical properties of these cyclometalated compounds will be tuned to maximize their benefits, which include catalysis and anti-cancer agents. Second, studying the regiochemistry of C-H and C-X bond activation will be examined in the area of synthetic chemistry. Third, several multi-heteronuclear species will be synthesized and their interaction with biomolecules, such as proteins, DNA, and RNA will be examined

在这个由化学系化学结构、动力学和机理B项目资助的项目中，巴德学院化学系的Craig M. Anderson教授将研究过渡环金属化配合物的合成。这些配合物的研究可能会促进对基本催化反应的理解，并最终在具有能源意义的领域做出贡献，因为环金属化配合物在人工光合装置的研究中是众所周知的。这项工作的另一个非常重要的方面是，它将涉及从一年级到高年级的所有层次的本科生。它还将使学生获得许多不同技能和技术的经验，如合成、表征和结果分析。学生将得到良好的训练，以便继续进一步的科学研究，通过书面出版物和口头报告传播他们的工作，并提出新的假设进行测试。环金属化过渡金属配合物是一种用途广泛的化合物，其应用范围包括催化剂、传感器、人工光合作用装置和生物有机金属剂。了解配体结构对环金属化配合物的选择性和反应活性的影响是很重要的，因为配位环境决定了反应的功能和功效。首先，这些环金属化化合物的物理和化学性质将被调整，以最大限度地发挥其效益，包括催化和抗癌剂。其次，研究C-H和C-X键激活的区域化学将在合成化学领域进行研究。第三，将合成几种多异核物种，并研究它们与蛋白质、DNA和RNA等生物分子的相互作用