Understanding and Directing the Reactivity of Cyclometalated Complexes in Late Transition Metal-Based Homogeneous Catalysis
了解和指导环金属配合物在后过渡金属均相催化中的反应活性
基本信息
- 批准号:1800467
- 负责人:
- 金额:$ 46.2万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With funding from the Chemical Catalysis Program of the Division of Chemistry, Dr. Pinjing Zhao of North Dakota State University Fargo is studying metal-based catalysts for the synthesis of organic molecules. Metal catalysts, molecules that speed up reactions, must interact with the target starting materials (substrates) in order to transform the reactants into products. Dr. Zhao is studying the rational design and development of new catalysts, including those that do not employ expensive and rare metals, to provide new tools for environmentally-friendly chemical synthesis. This project provides interdisciplinary research training and career preparation for graduate and undergraduate students. Catalytic and synthetic reactions are introduced in the sophomore organic chemistry lecture course. Student projects are developed for the inorganic laboratory course to provide hands-on experience with instrumentation and lab techniques. Professor Zhao leads the construction of a web-based database to promote general dissemination of the fundamental knowledge and recent research progress on organometallic chemistry. This database provides valuable training experiences for graduate and undergraduate students training them for careers in industry, government and academia. Dr. Zhao is developing catalytic applications of late transition metal-based cyclometalation processes. Catalytically-relevant metallacycles are generated through nickel- and ruthenium-mediated C-H bond activation of ancillary ligands such as N-heterocyclic carbenes (NHCs) and aromatic N-H ketimines. Other target cyclometalation processes include rhodium- and ruthenium-mediated decarboxylation of arene- and heteroarenecarboxylic acids via chelation assistance. Results of structure-reactivity relationships of cyclometalated catalyst precursors and reactive intermediates are guiding new catalyst developments via atom-efficient activation of strong chemical bonds including carbon-hydrogen, oxygen-hydrogen, and carbon-carbon bonds. Dr. Zhao is also leading an initiative to develop a web-based searchable database to promote general dissemination of fundamental knowledge on chemical bond transformations in organometallic chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系化学催化项目的资助下,北达科他州立大学法戈分校的赵pinjing博士正在研究用于有机分子合成的金属基催化剂。金属催化剂是加速反应的分子,必须与目标起始材料(底物)相互作用,才能将反应物转化为产物。Zhao博士正在研究新型催化剂的合理设计和开发,包括那些不使用昂贵和稀有金属的催化剂,为环境友好的化学合成提供新的工具。该项目为研究生和本科生提供跨学科的研究训练和职业准备。在二年级的有机化学讲座中,介绍了催化和合成反应。学生项目是为无机实验课程开发的,提供仪器和实验技术的实践经验。Zhao教授领导了一个基于网络的数据库的建设,以促进有机金属化学基础知识和最新研究进展的普遍传播。该数据库为研究生和本科生提供宝贵的培训经验,培训他们在工业、政府和学术界的职业生涯。Zhao博士正在开发晚期过渡金属基环金属化工艺的催化应用。催化相关的金属环是通过镍和钌介导的C-H键激活辅助配体如n -杂环碳烯(NHCs)和芳香N-H酮胺而产生的。其他靶环金属化过程包括铑和钌介导的芳烃和杂芳烃羧酸通过螯合辅助脱羧。环金属化催化剂前体和反应中间体的结构-反应关系的研究结果通过原子高效激活强化学键(包括碳-氢、氧-氢和碳-碳键)来指导新型催化剂的开发。Zhao博士还领导了一项倡议,开发一个基于网络的可搜索数据库,以促进有机金属化学中化学键转化基础知识的普遍传播。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Pinjing Zhao其他文献
Exploring Bis(cyclometalated) Ruthenium(II) Complexes as Active Catalyst Precursors: Room‐Temperature Alkene‐Alkyne Coupling for 1,3‐Diene Synthesis.
探索双(环金属化)钌(II)络合物作为活性催化剂前体:用于 1,3-二烯合成的室温烯烃-炔烃偶联。
- DOI:
10.1002/chin.201504073 - 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Jing Zhang;A. Ugrinov;Yong Zhang;Pinjing Zhao - 通讯作者:
Pinjing Zhao
Transfer of amido groups from isolated rhodium(I) amides to alkenes and vinylarenes.
将酰胺基从分离的铑(I)酰胺转移至烯烃和乙烯基芳烃。
- DOI:
10.1021/ja052473h - 发表时间:
2005 - 期刊:
- 影响因子:15
- 作者:
Pinjing Zhao;C. Krug;J. Hartwig - 通讯作者:
J. Hartwig
Recent Applications of Triarylmethyl (TAM) Derivatives as Electron Paramagnetic Resonance (EPR) Spin Labels in Biomacromolecular Structural Studies
- DOI:
10.1007/s00723-023-01567-2 - 发表时间:
2023-08-25 - 期刊:
- 影响因子:1.100
- 作者:
Zoe Armstrong;Austin MacRae;Mary Lenertz;Qiaobin Li;Grace Blair;William Brown;Li Feng;Pinjing Zhao;Zhongyu Yang - 通讯作者:
Zhongyu Yang
Pinjing Zhao的其他文献
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{{ truncateString('Pinjing Zhao', 18)}}的其他基金
Rational Design of Eco-Friendly Homogeneous Catalysis by Rhodium- and Ruthenium-Catalyzed C-H Bond Activation and Decarboxylation
铑和钌催化 C-H 键活化和脱羧的环保均相催化的合理设计
- 批准号:
1301409 - 财政年份:2013
- 资助金额:
$ 46.2万 - 项目类别:
Continuing Grant
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