Cell Phone Based Polarized Light Imaging

1402846代码这项提议的目标是开发一种变革性的低成本、高质量、非侵入性、基于手机的光学偏振成像系统，用于医疗保健应用。具体目标是设计、建模、构建和测试该系统，并开发基于Android的应用程序，用于控制手机摄像头功能和执行图像处理。该系统将利用单透镜芯片上白光偏振成像，通过检测偏振光通过组织或血液样本时线性状态的变化，帮助诊断几种疾病。有许多情况会引起偏振光的变化，该设备旨在帮助临床和低资源环境中的医疗专业人员正确诊断这些情况。开发该设备的最初应用包括在体诊断皮肤癌，如基底细胞癌(BCC)、黑色素瘤和鳞状细胞癌(SCC)，以及在实验室或现场进行疟疾的体外检测。

1402846CoteThe goal of this proposal is to develop a transformative low cost, high quality, noninvasive, cellphone-based, optical polarimetric imaging system for point-of-care applications. The specific aims are to design, model, build, and test the system and to develop android based applications for controlling cell phone camera features and perform image processing. This system will utilize a single lens on-chip white light polarized imaging to aid in the diagnosis of several diseases through the detection of variations in the linear states of polarized light as it passes through tissue or blood sample. There are many conditions that induce changes in polarized light and the device is meant to assist medical professionals in the clinic and in low resource settings in the proper diagnosis of these conditions. The initial applications for developing this device include in vivo diagnosis of skin cancers such as basal cell carcinoma (BCC), melanoma, and squamous cell carcinoma (SCC) and in vitro detection of malaria in the lab or in the field.