Cell Phone Based Physical Activity Program in Sedentary Women and Men

描述(由申请人提供)：这是为加州大学旧金山分校生理护理系的福冈吉美博士申请K23奖项。福冈博士在以患者为导向的体力活动临床研究项目中确立了自己的年轻研究员身份，该项目涉及创新的手机技术。这一K23奖项将为福冈博士提供必要的支持，以实现以下目标：(1)对一种新型的基于手机的干预进行临床研究，以增加男性和女性的体力活动，(2)在随机对照临床试验中应用先进的生物统计学方法，(3)开发和应用移动说服(Captology)来促进健康和疾病预防研究，(4)在临床研究中实施焦点小组，以及(5)发展独立的临床研究事业。为了实现这些目标，福冈博士组建了一个指导团队，成员包括主要导师、加州大学旧金山分校护理学院教授兼院长、临床试验人员凯瑟琳·德拉库普博士、共同导师、专注于社区体育活动的国际公认的体力活动和健康专家威廉·哈斯克尔博士以及3名科学顾问：研究设计和当前最先进的生物统计分析专家Eric Vittinghoff博士；擅长定性研究的Teri Lindgren博士；以及擅长开发移动应用程序的Holger Assenmacher博士。有规律的体育锻炼可以降低超重的风险，从而降低心脏病、中风、高血压、糖尿病、某些癌症和过早死亡的风险。然而，超过一半的美国成年人身体不活跃。福冈博士将领导焦点小组，探索使用手机对久坐不动的男性和女性进行体力活动干预的可接受性(目标1)。然后，福冈博士将进行一项试点随机对照临床试验，以评估基于手机的体力活动干预对久坐不动的男性和女性的有效性和长期依从性的初步估计(目标2)。这些研究的结果将成为随机对照临床试验的基础，以测试基于手机的体力活动计划在久坐的成年人中的有效性。NIH R01拨款申请将在K奖结束前提交。 公共卫生相关性： 尽管有规律的体育锻炼对健康有益，但在美国，大约有一半的成年人从事推荐水平的体育锻炼。为了接触到更多久坐不动的成年人，我们将应用手机技术作为一种手段来提供体育活动计划，并激励参与者，从而实现他们的体育活动目标。

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Yoshimi Fukuoka in the Department of Physiological Nursing at the University of California, San Francisco. Dr. Fukuoka is establishing herself as a young investigator in patient-oriented clinical research of physical activity program that involves innovative cell phone technologies. This K23 award will provide Dr. Fukuoka with the support necessary to accomplish the following goals: (1) to conduct clinical investigations of a novel cell phone-based intervention to increase physical activity in men and women, (2) to implement advanced biostatistical methods in randomized controlled clinical trials, (3) to develop and apply mobile persuasion (captology) to health promotion and disease prevention research, (4) to implement focus groups in clinical studies, and (5) to develop an independent clinical research career. To achieve these goals, Dr. Fukuoka has assembled a mentoring team comprised of a primary mentor, Dr. Kathleen Dracup, Professor and Dean of the School of Nursing at UCSF, who is a clinical trialist; a co-mentor, Dr. William Haskell, who is an internationally recognized expert in physical activity and health who focuses on community-based physical activity; and 3 scientific advisors: Dr. Eric Vittinghoff, an expert in study design and current state-of-the-art biostatistical analysis; Dr. Teri Lindgren, who has expertise in qualitative research; and Dr. Holger Assenmacher, who has expertise in the development of mobile applications. Regular physical activity reduces the risk of being overweight, thereby reducing the risk of heart disease, stroke, hypertension, diabetes, certain cancers, and premature mortality. Yet, more than half of the U.S. adults are physically inactive. Dr. Fukuoka will conduct focus groups to explore the acceptability of using cell phones to deliver a physical activity intervention in sedentary men and women (Aim 1). Dr. Fukuoka will then conduct a pilot randomized, controlled, clinical trial to assess preliminary estimates of efficacy and long-term adherence of a cell phone-based physical activity intervention in sedentary men and women (Aim 2). The results from these studies will form the basis for a randomized controlled clinical trail to test efficacy of the cell phone-based physical activity program in sedentary adults. An NIH R01 grant application will be submitted before the end of the K award. PUBLIC HEALTH RELEVANCE: Despite the health benefits of regular physical activity, approximately half of adult adults in the United States engage in recommended levels of physical activity. To reach a larger population of sedentary adults, we will apply cell phone technologies as a means to deliver a physical activity program and to motivate participants so that their physical activity goals can be achieved.