Cell Phone Based Physical Activity Program in Sedentary Women and Men

描述（由申请人提供）：这是加州大学旧金山分校生理护理系Yoshimi Fukuoka博士的K23奖申请。福冈博士将自己定位为一名年轻的研究人员，从事以患者为导向的体育活动临床研究项目，该项目涉及创新的手机技术。该K23奖将为福冈博士提供必要的支持，以实现以下目标：(1)开展基于手机的新型干预措施的临床研究，以增加男性和女性的身体活动；(2)在随机对照临床试验中实施先进的生物统计学方法；(3)在健康促进和疾病预防研究中发展和应用移动说服（captology）；(4)在临床研究中实施焦点小组；(5)发展独立的临床研究事业。为了实现这些目标，福冈博士组建了一个指导团队，其中包括一位主要导师，加州大学旧金山分校护理学院教授兼院长凯瑟琳·德拉库普博士，她是一名临床试验学家；共同导师William Haskell博士，他是国际公认的身体活动与健康专家，专注于社区身体活动；和3名科学顾问：Eric Vittinghoff博士，研究设计和当前最先进的生物统计分析专家；泰瑞·林德格伦博士，擅长定性研究；以及Holger Assenmacher博士，他在移动应用程序开发方面具有专业知识。有规律的体育活动可以降低超重的风险，从而降低患心脏病、中风、高血压、糖尿病、某些癌症和过早死亡的风险。然而，超过一半的美国成年人缺乏体育锻炼。Dr. Fukuoka将组织焦点小组探讨在久坐不动的男性和女性中使用手机进行身体活动干预的可接受性（目的1）。然后，Fukuoka博士将进行一项随机对照临床试验，以评估基于手机的身体活动干预对久坐不动的男性和女性的疗效和长期依从性的初步估计（目标2）。这些研究的结果将构成随机对照临床试验的基础，以测试基于手机的体育活动项目对久坐不动的成年人的有效性。NIH R01拨款申请将在K奖结束前提交。

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. Yoshimi Fukuoka in the Department of Physiological Nursing at the University of California, San Francisco. Dr. Fukuoka is establishing herself as a young investigator in patient-oriented clinical research of physical activity program that involves innovative cell phone technologies. This K23 award will provide Dr. Fukuoka with the support necessary to accomplish the following goals: (1) to conduct clinical investigations of a novel cell phone-based intervention to increase physical activity in men and women, (2) to implement advanced biostatistical methods in randomized controlled clinical trials, (3) to develop and apply mobile persuasion (captology) to health promotion and disease prevention research, (4) to implement focus groups in clinical studies, and (5) to develop an independent clinical research career. To achieve these goals, Dr. Fukuoka has assembled a mentoring team comprised of a primary mentor, Dr. Kathleen Dracup, Professor and Dean of the School of Nursing at UCSF, who is a clinical trialist; a co-mentor, Dr. William Haskell, who is an internationally recognized expert in physical activity and health who focuses on community-based physical activity; and 3 scientific advisors: Dr. Eric Vittinghoff, an expert in study design and current state-of-the-art biostatistical analysis; Dr. Teri Lindgren, who has expertise in qualitative research; and Dr. Holger Assenmacher, who has expertise in the development of mobile applications. Regular physical activity reduces the risk of being overweight, thereby reducing the risk of heart disease, stroke, hypertension, diabetes, certain cancers, and premature mortality. Yet, more than half of the U.S. adults are physically inactive. Dr. Fukuoka will conduct focus groups to explore the acceptability of using cell phones to deliver a physical activity intervention in sedentary men and women (Aim 1). Dr. Fukuoka will then conduct a pilot randomized, controlled, clinical trial to assess preliminary estimates of efficacy and long-term adherence of a cell phone-based physical activity intervention in sedentary men and women (Aim 2). The results from these studies will form the basis for a randomized controlled clinical trail to test efficacy of the cell phone-based physical activity program in sedentary adults. An NIH R01 grant application will be submitted before the end of the K award. PUBLIC HEALTH RELEVANCE: Despite the health benefits of regular physical activity, approximately half of adult adults in the United States engage in recommended levels of physical activity. To reach a larger population of sedentary adults, we will apply cell phone technologies as a means to deliver a physical activity program and to motivate participants so that their physical activity goals can be achieved.