Chiral 3d-transition metal catalysts on the basis of novel tetradentate bis(iminoalkoxid) ligands and their investigation in the asymmetric catalysis of multiple bond transformations (epoxidation, alkynylation of ketones)

对于制药行业来说，获得对映体纯度高的产品是非常重要的，因为通常只有一种对映体具有相应的药理作用。因此，手性分子的对映选择性合成是研究的热点。实现这一目标的一种方法是使用手性催化剂。有了它们，就有可能进行原子高效合成，从而避免浪费。这在经济上和生态上都是明智的。因此，本课题应开发具有新型手性、四齿双（亚氨基醇）配体的不对称催化剂。首先，应合成具有三维过渡金属（钛、铬、锰、铁、铜、锌）的不同配合物。此外，还应尝试合成双金属配合物，因为这些配合物由于协同效应可能具有更好的催化性能。该配合物的性质应在多键转化（环氧化，酮的炔化）的不对称催化中进行测试。通过改变配体的取代基，催化剂应该得到优化，以实现高对映体过量。总之，应该开发一种廉价的、高度可变的手性配体体系，它易于合成，其配合物能够在催化方面与已有的salen配合物竞争。

For the pharmaceutical industry, it is of great interest to obtain enantiomerically pure products, since normally only one enantiomer shows the corresponding pharmacological effect. Accordingly, the enantioselective synthesis of chiral molecules is subject of intense research. One way to accomplish this is through the use of chiral catalysts. With them it is possible to perform atom efficient synthesis and thus avoid waste. This is both economically and ecologically wise.Therefore, asymmetric catalysts with novel chiral, tetradentate bis(iminoalcohol) ligands should be developed in this research project. Initially, different complexes with 3d transition metals (titanium, chromium, manganese, iron, copper, zinc) should be synthesized. In addition the synthesis of bimetallic complexes should be tried, since these could have better catalytic properties due to cooperative effects. The properties of the complexes should be tested in the asymmetric catalysis of multiple bond transformations (epoxidation, alkynylation of ketones). By varying the substituents of the ligand, the catalysts should get optimized to achieve high enantiomeric excesses. Overall, an inexpensive and highly variable, chiral ligand system should be developed that is easy to synthesize and its complexes are able to compete in catalysis with the established salen complexes.