The Response of Brain Cells to Traumatic Injury
脑细胞对创伤的反应
基本信息
- 批准号:1404716
- 负责人:
- 金额:$ 39.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-01 至 2018-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Traumatic brain injury is a diverse and complex injury that affects 1.7 million Americans annually. Survivors frequently have permanent cognitive loss, behavioral issues, and emotional disturbances that affect them throughout their life. These life-altering changes are likely caused by damage to the cells of the brain that occur in response to injury. What remains unclear is how the behavior of brain cells is influenced by the events that occur during injury. To explore the response of brain cells to traumatic brain injury the research team has developed a novel bench top crash tester. Similar in concept to the full scale crash test systems used by the automotive industry, the bench top system will be used to apply impact conditions to populations of brain cells grown in the lab. The knowledge gained from this research program could help illuminate the poorly understood cellular changes that follow traumatic brain injuries and help guide the development of new therapies. The project will have broader impacts on neuroscience, biomedical engineering, and the healthcare field. The research will be complemented by integrated educational projects at the undergraduate and high school academic levels that are designed to motivate scientific participation.Astrocytes are ubiquitous cells throughout brain tissue that play an essential role in neuronal survival. Yet, the mechanobiology of astrocytes, and in particular how their neuro-supportive role is affected by the mechanical stimuli that are generated during traumatic brain injury is not well understood. This research program will explore the mechanobiology of astrocytes, and investigate the hypothesis that the neuro-degenerative extracellular matrix environment produced by astrocytes following traumatic brain injury is triggered by mechanical stimuli. To explore this hypothesis, the research team will employ a custom impact bioreactor and cell culture system to (1) precisely apply traumatic brain injury mimetic impacts to populations of astrocytes in culture and (2) concentrate and collect the soluble (growth factors and cytokines) and insoluble (extracellular matrix) molecules released in response to impact loading. An improved understanding of the relationship between impact stimuli and the production of soluble and insoluble molecules will help elucidate the role astrocytes play in the neuro-degeneration processes that follow traumatic brain injury.
创伤性脑损伤是一种多样而复杂的损伤,每年影响170万美国人。幸存者经常有永久性的认知丧失,行为问题和情绪困扰,影响他们的一生。这些改变生命的变化可能是由大脑细胞对损伤的反应引起的。目前尚不清楚的是,脑细胞的行为如何受到损伤期间发生的事件的影响。为了探索脑细胞对创伤性脑损伤的反应,研究小组开发了一种新型的台式碰撞测试仪。类似于汽车工业使用的全尺寸碰撞测试系统的概念,台式系统将用于将冲击条件应用于实验室中生长的脑细胞群体。从这项研究计划中获得的知识可以帮助阐明创伤性脑损伤后鲜为人知的细胞变化,并帮助指导新疗法的开发。该项目将对神经科学、生物医学工程和医疗保健领域产生更广泛的影响。该研究将通过本科和高中学术水平的综合教育项目来补充,这些项目旨在激励科学参与。星形胶质细胞是遍布脑组织的细胞,在神经元存活中发挥重要作用。然而,星形胶质细胞的机械生物学,特别是它们的神经支持作用如何受到创伤性脑损伤期间产生的机械刺激的影响还没有很好的理解。本研究计划将探讨星形胶质细胞的机械生物学,并调查创伤性脑损伤后星形胶质细胞产生的神经退行性细胞外基质环境是由机械刺激触发的假设。为了探索这一假设,研究小组将采用定制的冲击生物反应器和细胞培养系统来(1)精确地将创伤性脑损伤模拟冲击应用于培养中的星形胶质细胞群体,以及(2)浓缩和收集响应冲击负荷释放的可溶性(生长因子和细胞因子)和不溶性(细胞外基质)分子。对冲击刺激与可溶性和不溶性分子产生之间关系的进一步理解将有助于阐明星形胶质细胞在创伤性脑损伤后神经变性过程中的作用。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeffrey Wolchok其他文献
Jeffrey Wolchok的其他文献
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{{ truncateString('Jeffrey Wolchok', 18)}}的其他基金
Cell Derived Extracellular Matrix BIofiber Engineering
细胞衍生的细胞外基质生物纤维工程
- 批准号:
2320185 - 财政年份:2023
- 资助金额:
$ 39.57万 - 项目类别:
Standard Grant
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